Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.31 extracted from

  • Sidani, S.; Kopic, S.; Socrates, T.; Kirchhoff, P.; Foeller, M.; Murek, M.; Capasso, A.; Geibel, J.P.
    AMP-activated protein kinase: a physiological off switch for murine gastric acid secretion (2009), Pflugers Arch., 459, 39-46.
    View publication on PubMed
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
5-aminoimidazole-4-carboxamide-1-beta-D-riboside AICAR, activates AMPK, whereby significantly reduces secretagogue-induced acid secretion Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
6-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine compound C, inhibits AMPK, whereby restores acid secretion Mus musculus
ATP inhibits AMPK, whereby restores acid secretion Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gastric gland
-
 Mus musculus
-
gastric mucosa
-
 Mus musculus
-
additional information parietal cell Mus musculus
-

Synonyms

Synonyms Comment Organism
adenosine monophosphate-activated protein kinase
-
 Mus musculus
AMP-activated protein kinase
-
 Mus musculus
AMPK
-
 Mus musculus

General Information

General Information Comment Organism
metabolism is a metabolic energy regulator that can switch acid secretion off as cellular ATP levels fall. Secretagogue-induced acid secretion can be significantly reduced with AMPK activation and restored with its deactivation Mus musculus