Literature summary for 2.7.11.31 extracted from

Frederich, M.; ORourke, M.R.; Furey, N.B.; Jost, J.A.
AMP-activated protein kinase (AMPK) in the rock crab, Cancer irroratus: an early indicator of temperature stress (2009), J. Exp. Biol., 212, 722-730.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	the region flanking the regulatory T172 site of AMPKalpha subunit is phosphorylated by an upstream AMPKK. AMPK is activated during temperature stress. AMPK activity remains constant between 12 and 18°C, but increases up to 9.1fold between 18 and 30°C. Total AMPK protein expression levels do not vary significantly over this temperature range. Prolonged exposure for up to 6 h to the sublethal temperature of 26°C leads to a constant elevation of AMPK activity. Increase in AMPK activity above 18°C coincides with the decrease in reaction time	Cancer irroratus

Application

Application	Comment	Organism
additional information	AMPK is an earlier indicator of temperature stress in rock crabs than HSP70, especially during the initial response to high temperatures. AMPK activity is a cellular marker that indicates a thermal threshold, called the pejus temperature	Cancer irroratus

Organism

Organism	UniProt	Comment	Textmining
Cancer irroratus	B8Y8L1	AMPKgamma subunit	-
Cancer irroratus	B8Y8L2	AMPKalpha	-

Synonyms

Synonyms	Comment	Organism
AMP-activated protein kinase	-	Cancer irroratus
AMPK	-	Cancer irroratus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
28	-	-	Cancer irroratus

Expression

Organism	Comment	Expression
Cancer irroratus	AMPKalpha mRNA levels increase continuously throughout exposure to 26°C, reaching 5.6times more after 6 h at 26°C than in the 12°C controls	up

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Release 2023.1 (January 2023)