Literature summary for 2.7.11.31 extracted from

Chan, A.Y.; Dolinsky, V.W.; Soltys, C.L.; Viollet, B.; Baksh, S.; Light, P.E.; Dyck, J.R.
Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt (2008), J. Biol. Chem., 283, 24194-24201.

Search for more literature for 2.7.11.31

Activating Compound

Activating Compound	Comment	Organism	Structure
resveratrol	increases the phosphorylation status of AMPK in wild-type MEFs. Effect of resveratrol on AMPK is mediated via LKB1	Mus musculus
resveratrol	resveratrol exerts anti-hypertrophic effects by activating AMPK via LKB1 and inhibiting Akt, thus suppressing protein synthesis and gene transcription. Level of phosphorylated AMPK is significantly increased in resveratrol-treated cardiac myocytes in the absence or presence of phenylephrine	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cardiac myocyte	-	Rattus norvegicus	-
MEF cell	mouse embryonic fibroblasts	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + acetyl-CoA carboxylase	-	Mus musculus	ADP + [acetyl-CoA carboxylase]phosphate	-	?
ATP + acetyl-CoA carboxylase	-	Rattus norvegicus	ADP + [acetyl-CoA carboxylase]phosphate	-	?

Synonyms

Synonyms	Comment	Organism
AMP-activated protein kinase	-	Mus musculus
AMP-activated protein kinase	-	Rattus norvegicus
AMPK	-	Mus musculus
AMPK	-	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)