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Literature summary for 2.7.11.31 extracted from

  • Setsuie, R.; Suzuki, M.; Kabuta, T.; Fujita, H.; Miura, S.; Ichihara, N.; Yamada, D.; Wang, Y.L.; Ezaki, O.; Suzuki, Y.; Wada, K.
    Ubiquitin C-terminal hydrolase-L3-knockout mice are resistant to diet-induced obesity and show increased activation of AMP-activated protein kinase in skeletal muscle (2009), FASEB J., 23, 4148-4157.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information in skeletal muscle of Uchl3-/- mice fed a normal chow diet, phosphorylated AMPK is significantly up-regulated, which indicates an increased activation of AMPK, in any feeding state. No AMPK activation in other major metabolic tissues, such as liver and white adipose tissue. Embryonic fibroblasts derived from Uchl3-/- mice also show increased activation of AMPK, indicating that UCH-L3 is involved in a cell-autonomous down-regulation of AMPK Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information UCH-L3 is involved in a cell-autonomous down-regulation of AMPK activity Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic fibroblast
-
 Mus musculus
-
skeletal muscle
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Mus musculus
AMPK
-
 Mus musculus

General Information

General Information Comment Organism
physiological function AMPK activation and subsequent increases in fatty acid beta-oxidation in skeletal muscle leads to increased energy expenditure in Uchl3-/- mice Mus musculus