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Literature summary for 2.7.11.31 extracted from

  • Gao, Y.; Zhou, Y.; Xu, A.; Wu, D.
    Effects of an AMP-activated protein kinase inhibitor, compound C, on adipogenic differentiation of 3T3-L1 cells (2008), Biol. Pharm. Bull., 31, 1716-1722.
    View publication on PubMed
Search for more literature for 2.7.11.31

Application

Application Comment Organism
drug development the AMPK inhibitor 6-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine may serve as a useful molecule in both basic and clinical research on adipogenesis and as a potential lead compound for the treatment of obesity Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
6-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine inhibits AMPK in a dose dependent manner. Suppresses AMPK activity during the early phase of adipogenic differentiation, which indicates that suppressed activation of AMPK may inhibit the mitotic clonal expansion process of preadipocytes. Levels of phosphorylated AMPKalpha and total AMPKalpha are not affected by 6-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
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 Mus musculus
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preadipocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA carboxylase
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 Mus musculus ADP + phosphorylated acetyl-CoA carboxylase
-
 ?

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
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 Mus musculus
AMPK
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 Mus musculus