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Literature summary for 2.7.11.31 extracted from

  • Choi, J.S.; Park, C.; Jeong, J.W.
    AMP-activated protein kinase is activated in Parkinsons disease models mediated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (2010), Biochem. Biophys. Res. Commun., 391, 147-151.
    View publication on PubMed
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine activates AMPK, phosphorylation of AMPK-Thr172 is increased 2.8fold in the degenerated midbrain by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxication. AMPK activation is stimulated in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice Mus musculus
1-methyl-4-phenylpyridinium activates AMPK in SH-SY5Y cells. Increases phosphorylation level at Thr172 in the active site of AMPKalpha. AMPK is activated during the progression of cell death mediated by 1-methyl-4-pyridinium Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
wild-type AMPK transiently transfected into SH-SY5Y cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
6-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine compound C, potent AMPK inhibitor, inhibition results in an increase in 1-methyl-4-pyridinium-induced cell death. Prevents the AMPK activation by 1-methyl-4-pyridinium and stimulates 1-methyl-4-pyridinium-induced cell death Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Mus musculus
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 male C57BL/6 mice
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Source Tissue

Source Tissue Comment Organism Textmining
midbrain
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 Mus musculus
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SH-SY5Y cell
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 Homo sapiens
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substantia nigra
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 Mus musculus
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Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
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 Mus musculus
AMP-activated protein kinase
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 Homo sapiens
AMPK
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 Mus musculus
AMPK
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 Homo sapiens

General Information

General Information Comment Organism
physiological function activation of AMPK may prevent neuronal cell death and play a role as a survival factor in Parkinson's disease Mus musculus
physiological function activation of AMPK may prevent neuronal cell death and play a role as a survival factor in Parkinson's disease. Overexpression of AMPK increases cell viability after exposure to 1-methyl-4-pyridinium in SH-SY5Y cells Homo sapiens