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Literature summary for 2.7.11.31 extracted from

  • McFadden, J.W.; Corl, B.A.
    Activation of AMP-activated protein kinase (AMPK) inhibits fatty acid synthesis in bovine mammary epithelial cells (2009), Biochem. Biophys. Res. Commun., 390, 388-393.
    View publication on PubMed
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
5-aminoimidazole-4-carboxamide riboside AICAR, increases phosphorylation of alpha1 AMPK, resulting in inactivation of ACCalpha in MAC-T cells Bos taurus
additional information decreases in energy availability or rises in intracellular Ca2+ most likely activates AMPK in MAC-T cell Bos taurus

Application

Application Comment Organism
industry AMPK as a molecular target capable of modifying energy substrate utilization may result in the development of new technologies that increase milk production or modify milk composition during periods of increased energy demand Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
adipose bull, presence of alpha, beta, and gamma isoforms of AMPK Bos taurus
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liver bull, presence of alpha, beta, and gamma isoforms of AMPK Bos taurus
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mammary epithelial cell MAC-T cells from Holstein and Jersey cows Bos taurus
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mammary gland
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 Bos taurus
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muscle bull, presence of alpha, beta, and gamma isoforms of AMPK Bos taurus
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Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
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 Bos taurus
AMPK
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 Bos taurus

Expression

Organism Comment Expression
Bos taurus relative expression of alpha, beta, and gamma isoforms of AMPK is greatest in muscle and MAC-T cells up

General Information

General Information Comment Organism
physiological function AMPK activation dramatically decreases de novo fatty acid synthesis and inactivates ACCalpha. AMPK activation modifies lipogenic gene expression including fatty acid synthase, glycerol-3-phosphate acyltransferase, and fatty acid binding protein-3. AMPK is able to inhibit fatty acid synthesis, an energy consuming process, in response to decreases in energy supply Bos taurus