Activating Compound | Comment | Organism | Structure |
---|---|---|---|
AMP | - |
Ovis aries | |
additional information | phosphorylation of AMPK at Thr172 of the alpha-subunit activates the enzyme | Ovis aries |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Ovis aries |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [acetyl-CoA carboxylase] | Ovis aries | phosphorylation at Ser79 | ADP + [acetyl-CoA carboxylase] phosphate | - |
? | |
additional information | Ovis aries | AMPK signalling pathways are downregulated and skeletal muscle development is impaired in fetuses of obese, over-nourished sheep without differences in energy status, i.e. the AMP/ATP ratio, overview. Decreased signalling of the AMPK system in skeletal muscle of fetuses of OB mothers may play a role in altered muscle development and development of insulin resistance in the offspring | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ovis aries | - |
obese ewes | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation of AMPK at Thr172 of the alpha-subunit | Ovis aries |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fetus | - |
Ovis aries | - |
skeletal muscle | fetal, semitendinosus | Ovis aries | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [acetyl-CoA carboxylase] | phosphorylation at Ser79 | Ovis aries | ADP + [acetyl-CoA carboxylase] phosphate | - |
? | |
additional information | AMPK signalling pathways are downregulated and skeletal muscle development is impaired in fetuses of obese, over-nourished sheep without differences in energy status, i.e. the AMP/ATP ratio, overview. Decreased signalling of the AMPK system in skeletal muscle of fetuses of OB mothers may play a role in altered muscle development and development of insulin resistance in the offspring | Ovis aries | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AMP-activated protein kinase | - |
Ovis aries |
AMPK | - |
Ovis aries |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Ovis aries |