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Literature summary for 2.7.11.31 extracted from

  • Han, J.H.; Ahn, Y.H.; Choi, K.Y.; Hong, S.H.
    Involvement of AMP-activated protein kinase and p38 mitogen-activated protein kinase in 8-Cl-cAMP-induced growth inhibition (2009), J. Cell. Physiol., 218, 104-112.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside i.e. AICAR, a potent agonist of AMPK, activates AMPK activation by p38 MAPK, AICAR must be phosphorylated itself to ZMP by adenosine kinases in order to activate AMPK Homo sapiens
8-chloro-cAMP induces AMPK phosphorylation Homo sapiens
AMP
-
Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of a dominant negative kinase-dead form of AMPKalpha2 in HeLa cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information enzyme inhibition by expression of a dominant negative expression vector with kinase-dead form of AMPKalpha2 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
compound C
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens AMP-activated protein kinase is involved in 8-chloro-cAMP-induced growth inhibition which proceeds via p38 MAPK and the metabolite 8-chloro-adenosine, AICAR must be phosphorylated to ZMP by adenosine kinases in order to activate AMPK, mechanism, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein 8-chloro-cAMP and no 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside induce AMPK phosphorylation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
heart healthy and ischemic Homo sapiens
-
HeLa cell
-
Homo sapiens
-
HL-60 cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-
MDA-MB-231 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [SAMS peptide]
-
Homo sapiens ADP + [SAMS peptide] phosphate
-
?
additional information AMP-activated protein kinase is involved in 8-chloro-cAMP-induced growth inhibition which proceeds via p38 MAPK and the metabolite 8-chloro-adenosine, AICAR must be phosphorylated to ZMP by adenosine kinases in order to activate AMPK, mechanism, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
AMPK
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens