Activating Compound | Comment | Organism | Structure |
---|---|---|---|
AMP | - |
Rattus norvegicus | |
additional information | cellular energy stress and other signals activate AMPK by various pathways, leading as a main consequence to compensatory measures that increase ATP generation and decrease ATP consumption | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expression of alpha1 subunit alone or in combination with other subunits in Escherichia coli | Rattus norvegicus |
expression of alpha2 subunit alone or in combination with other subunits in Escherichia coli | Rattus norvegicus |
expression of beta1 subunit alone or in combination with other subunits in Escherichia coli | Rattus norvegicus |
expression of beta2 subunit alone or in combination with other subunits in Escherichia coli | Rattus norvegicus |
expression of gamma1 subunit alone or in combination with other subunits in Escherichia coli | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | cellular energy stress and other signals activate AMPK by various pathways, leading as a main consequence to compensatory measures that increase ATP generation and decrease ATP consumption | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P54645 | alpha1 subunit | - |
Rattus norvegicus | P80385 | gamma1 subunit | - |
Rattus norvegicus | P80386 | beta1 subunit | - |
Rattus norvegicus | P80386 | beta2 subunit | - |
Rattus norvegicus | Q09137 | alpha2 subunit | - |
Purification (Comment) | Organism |
---|---|
recombinant untagged protein by automated multidimensional purification including adsorption chromatography and gel filtration, overview | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [peptide HMRSAMSGLHLVKRR] | i.e. SAMS peptide | Rattus norvegicus | ADP + [peptide HMRSAMSGLHLVKRR] phosphate | - |
? | |
additional information | cellular energy stress and other signals activate AMPK by various pathways, leading as a main consequence to compensatory measures that increase ATP generation and decrease ATP consumption | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
trimer | heterotrimer, complex structure determination and analysis by mass spectrometry, dynamic light and small-angle X-ray scattering and transmission electrom microscopy, modeling, overview | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
AMP-activated protein kinase | - |
Rattus norvegicus |
AMPK | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |