Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.31 extracted from

  • Lee, H.; Cho, J.S.; Lambacher, N.; Lee, J.; Lee, S.J.; Lee, T.H.; Gartner, A.; Koo, H.S.
    The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to oxidative stress and for normal motility and foraging behavior (2008), J. Biol. Chem., 283, 14988-14993.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
AMP
-
 Caenorhabditis elegans
additional information AAK-2 is phosphorylated at Thr243 and activated in response to paraquat treatment, the phosphorylation depends on PAR-4, the Caenorhabditis elegans LKB1 homologue Caenorhabditis elegans

Cloned(Commentary)

Cloned (Comment) Organism
expression of the GFP-tagged AAK-2 in transgenic worms Caenorhabditis elegans

Protein Variants

Protein Variants Comment Organism
additional information aak-2 mutation and par-4 knockdown increase the sensitivity of worms to paraquat, and the double deficiency does not further increase sensitivity Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Caenorhabditis elegans AMPK can influence the behavior of Caenorhabditis elegans worms in addition to its well known function in metabolic control, aak-1 and aak-2 affect paraquat sensitivity of adult worms, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein AAK-2 is phosphorylated at Thr243 in response to paraquat treatment, the phosphorylation depends on PAR-4, the Caenorhabditis elegans LKB1 homologue Caenorhabditis elegans

Source Tissue

Source Tissue Comment Organism Textmining
body wall muscle
-
 Caenorhabditis elegans
-
excretory gland
-
 Caenorhabditis elegans
-
gonad somatic gonad Caenorhabditis elegans
-
neuron
-
 Caenorhabditis elegans
-
pharynx
-
 Caenorhabditis elegans
-
ventral nerve cord
-
 Caenorhabditis elegans
-
vulva
-
 Caenorhabditis elegans
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information AMPK can influence the behavior of Caenorhabditis elegans worms in addition to its well known function in metabolic control, aak-1 and aak-2 affect paraquat sensitivity of adult worms, overview Caenorhabditis elegans ?
-
 ?

Synonyms

Synonyms Comment Organism
AAK-2
-
 Caenorhabditis elegans
AMP-activated protein kinase
-
 Caenorhabditis elegans
AMPK
-
 Caenorhabditis elegans