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Literature summary for 2.7.11.31 extracted from

  • Thomson, D.M.; Herway, S.T.; Fillmore, N.; Kim, H.; Brown, J.D.; Barrow, J.R.; Winder, W.W.
    AMP-activated protein kinase phosphorylates transcription factors of the CREB family (2008), J. Appl. Physiol., 104, 429-438.
    View publication on PubMed
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside i.e. AICAR, activates AMPK activity with substrate CREB about 3fold, and AMPK signaling in muscles but not in LBK1-KO mice, overview Mus musculus
AMP
-
 Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK293 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information LBK1-KO mice mutants show reduced phospho-AMPK content and AMPK activity, e.g. with substrate CREB, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
compound C i.e. dorsomorphin or 6-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine, a specific inhibitor of AMPK Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ATF1 Mus musculus important reaction in enhancement of transcriptional activity ADP + phospho-ATF1
-
 ?
ATP + ATF2 Mus musculus
-
 ADP + phospho-ATF2
-
 ?
ATP + CREB Mus musculus important reaction in enhancement of transcriptional activity ADP + phospho-CREB
-
 ?
ATP + CREB1 Mus musculus AMPK competes with protein kinase A for the Ser119 phosphorylation site ADP + phospho-CREB1
-
 ?
ATP + CREBL2 Mus musculus
-
 ADP + phospho-CREBL2
-
 ?
ATP + CREM Mus musculus important reaction in enhancement of transcriptional activity ADP + phospho-CREM
-
 ?
additional information Mus musculus AMPK is a regulator of gene transcription increasing mitochondrial proteins of oxidative metabolsim as well as hexokinase expression in muscles ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 wild-type Wistar and LBK1-KO mice
-

Source Tissue

Source Tissue Comment Organism Textmining
heart muscle Mus musculus
-
liver
-
 Mus musculus
-
skeletal muscle gastrocnemius, tibialis anterior, heart, and epitrochlearis muscle Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ATF1 important reaction in enhancement of transcriptional activity Mus musculus ADP + phospho-ATF1
-
 ?
ATP + ATF1 phosphorylation at Ser63 and Ser267, recombinant AMPK composed by subunits alpha2beta2gamma2 Mus musculus ADP + phospho-ATF1
-
 ?
ATP + ATF2
-
 Mus musculus ADP + phospho-ATF2
-
 ?
ATP + ATF2 recombinant AMPK composed by subunits alpha2beta2gamma2 Mus musculus ADP + phospho-ATF2
-
 ?
ATP + CREB important reaction in enhancement of transcriptional activity Mus musculus ADP + phospho-CREB
-
 ?
ATP + CREB phosphorylation at Ser98 and Ser133, recombinant AMPK composed by subunits alpha2beta2gamma2 Mus musculus ADP + phospho-CREB
-
 ?
ATP + CREB1 AMPK competes with protein kinase A for the Ser119 phosphorylation site Mus musculus ADP + phospho-CREB1
-
 ?
ATP + CREB1 phosphorylation at Ser119, recombinant AMPK composed by subunits alpha2beta2gamma2 Mus musculus ADP + phospho-CREB1
-
 ?
ATP + CREBL2
-
 Mus musculus ADP + phospho-CREBL2
-
 ?
ATP + CREBL2 recombinant AMPK composed by subunits alpha2beta2gamma2 Mus musculus ADP + phospho-CREBL2
-
 ?
ATP + CREM important reaction in enhancement of transcriptional activity Mus musculus ADP + phospho-CREM
-
 ?
ATP + CREM phosphorylation at Ser71 and Ser192, recombinant AMPK composed by subunits alpha2beta2gamma2 Mus musculus ADP + phospho-CREM
-
 ?
additional information AMPK is a regulator of gene transcription increasing mitochondrial proteins of oxidative metabolsim as well as hexokinase expression in muscles Mus musculus ?
-
 ?
additional information AMP-activated protein kinase phosphorylates transcription factors of the CREB family Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
trimer heterotrimer, different subunit variants Mus musculus

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Mus musculus
AMPK
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus