Activating Compound | Comment | Organism | Structure |
---|---|---|---|
5'-AMP | - |
Drosophila melanogaster | |
5'-AMP | - |
Saccharomyces cerevisiae | |
5'-AMP | - |
Arabidopsis thaliana | |
5'-AMP | - |
Giardia intestinalis | |
5'-AMP | - |
Trypanosoma brucei | |
5'-AMP | - |
Dictyostelium discoideum | |
5'-AMP | - |
Schizosaccharomyces pombe | |
5'-AMP | - |
Caenorhabditis elegans | |
5'-AMP | - |
Physcomitrium patens | |
5'-AMP | up to 10fold activation, AMP also promotes net phosphorylation at a critical threonine residue Thr172 within the kinase domain that can generate a further 100fold activation, the combined effect being 1000fold | Mus musculus | |
5'-AMP | up to 10fold activation, AMP also promotes net phosphorylation at a critical threonine residue Thr172 within the kinase domain that can generate a further 100fold activation, the combined effect being 1000fold | Homo sapiens | |
5'-AMP | up to 10fold activation, AMP also promotes net phosphorylation at a critical threonine residue Thr172 within the kinase domain that can generate a further 100fold activation, the combined effect being 1000fold | Rattus norvegicus | |
leptin | the classical adipokine, released from adipocytes, stimulates the alpha2 isoform of AMPK and hence fatty acid oxidation in skeletal muscle | Mus musculus | |
leptin | the classical adipokine, released from adipocytes, stimulates the alpha2 isoform of AMPK and hence fatty acid oxidation in skeletal muscle | Homo sapiens | |
leptin | the classical adipokine, released from adipocytes, stimulates the alpha2 isoform of AMPK and hence fatty acid oxidation in skeletal muscle | Rattus norvegicus | |
metformin | - |
Mus musculus | |
metformin | - |
Homo sapiens | |
metformin | - |
Rattus norvegicus | |
additional information | activating phosphorylation of AMPK at Thr172 of the alpha-subunit, e.g. by CaMKKbeta or LBK1, dephosphorylation by phosphatase PP2C | Homo sapiens | |
additional information | activating phosphorylation of AMPK at Thr172 of the alpha-subunit, e.g. by CaMKKbeta or LBK1, inhibiting dephosphorylation by phosphatase PP2C | Mus musculus | |
additional information | activating phosphorylation of AMPK at Thr172 of the alpha-subunit, e.g. by CaMKKbeta or LBK1, inhibiting dephosphorylation by phosphatase PP2C | Rattus norvegicus | |
thiazolidinediones | - |
Mus musculus | |
thiazolidinediones | - |
Homo sapiens | |
thiazolidinediones | - |
Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
drug development | pharmacological activators of AMPK can act as treatments for diabetes and the metabolic syndrome | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
alpha, beta and subunit encoding genes, phylogenetic trees | Drosophila melanogaster |
alpha, beta and subunit encoding genes, phylogenetic trees | Mus musculus |
alpha, beta and subunit encoding genes, phylogenetic trees | Homo sapiens |
alpha, beta and subunit encoding genes, phylogenetic trees | Rattus norvegicus |
alpha, beta and subunit encoding genes, phylogenetic trees | Saccharomyces cerevisiae |
alpha, beta and subunit encoding genes, phylogenetic trees | Arabidopsis thaliana |
alpha, beta and subunit encoding genes, phylogenetic trees | Giardia intestinalis |
alpha, beta and subunit encoding genes, phylogenetic trees | Trypanosoma brucei |
alpha, beta and subunit encoding genes, phylogenetic trees | Dictyostelium discoideum |
alpha, beta and subunit encoding genes, phylogenetic trees | Schizosaccharomyces pombe |
alpha, beta and subunit encoding genes, phylogenetic trees | Caenorhabditis elegans |
alpha, beta and subunit encoding genes, phylogenetic trees | Physcomitrium patens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | activating mutations in AMPK can cause heart disease, detailed overview | Homo sapiens |
additional information | construction of AMPK deficient fa/fa rats as a model for the metabolic syndrome, phenotype, overview. Activating mutations in AMPK can cause heart disease, detailed overview | Rattus norvegicus |
additional information | construction of AMPK deficient ob/ob mice as a model for the metabolic syndrome, phenotype, overview. Activating mutations in AMPK can cause heart disease, detailed overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | activating phosphorylation of AMPK at Thr172 of the alpha-subunit, e.g. by CaMKKbeta or LBK1, inhibiting dephosphorylation by phosphatase PP2C | Homo sapiens | |
additional information | activating phosphorylation of AMPK at Thr172 of the alpha-subunit, e.g. by CaMKKbeta or LBK1, inhibiting dephosphorylation by phosphatase PP2C | Mus musculus | |
additional information | activating phosphorylation of AMPK at Thr172 of the alpha-subunit, e.g. by CaMKKbeta or LBK1, inhibiting dephosphorylation by phosphatase PP2C | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Drosophila melanogaster | |
Mg2+ | - |
Mus musculus | |
Mg2+ | - |
Homo sapiens | |
Mg2+ | - |
Rattus norvegicus | |
Mg2+ | - |
Saccharomyces cerevisiae | |
Mg2+ | - |
Arabidopsis thaliana | |
Mg2+ | - |
Giardia intestinalis | |
Mg2+ | - |
Trypanosoma brucei | |
Mg2+ | - |
Dictyostelium discoideum | |
Mg2+ | - |
Schizosaccharomyces pombe | |
Mg2+ | - |
Caenorhabditis elegans | |
Mg2+ | - |
Physcomitrium patens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | AMPK regulates the energy balance both at the cellular and whole body level, disorders of it are obesity, type 2 diabetes and the metabolic syndrome, overview. Activating mutations in AMPK can cause heart disease. AMPK is regulated by the AMP/ATP ratio and upstream kinases, e.g. CaMKKbeta and LBK1, overview. AMPK activation inhibits activation of the mammalian target-of-rapamycin pathway by the insulin/insulin-like growth factor-1 pathway, probably via phosphorylation of TSC2, an upstream regulator of mTOR | ? | - |
? | |
additional information | Homo sapiens | AMPK regulates the energy balance both at the cellular and whole body level, disorders of it are obesity, type 2 diabetes and the metabolic syndrome, overview. Activating mutations in AMPK can cause heart disease. AMPK is regulated by the AMP/ATP ratio and upstream kinases, e.g. CaMKKbeta and LBK1, overview. AMPK activation inhibits activation of the mammalian target-of-rapamycin pathway by the insulin/insulin-like growth factor-1 pathway, probably via phosphorylation of TSC2, an upstream regulator of mTOR | ? | - |
? | |
additional information | Rattus norvegicus | AMPK regulates the energy balance both at the cellular and whole body level, disorders of it are obesity, type 2 diabetes and the metabolic syndrome, overview. Activating mutations in AMPK can cause heart disease. AMPK is regulated by the AMP/ATP ratio and upstream kinases, e.g. CaMKKbeta and LBK1, overview. AMPK activation inhibits activation of the mammalian target-of-rapamycin pathway by the insulin/insulin-like growth factor-1 pathway, probably via phosphorylation of TSC2, an upstream regulator of mTOR | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
- |
- |
Caenorhabditis elegans | - |
- |
- |
Dictyostelium discoideum | - |
- |
- |
Drosophila melanogaster | - |
- |
- |
Giardia intestinalis | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Physcomitrium patens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Schizosaccharomyces pombe | - |
- |
- |
Trypanosoma brucei | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | activating phosphorylation of AMPK at Thr172 of the alpha-subunit, e.g. by CaMKKbeta or LBK1, dephosphorylation by phosphatase PP2C | Mus musculus |
phosphoprotein | activating phosphorylation of AMPK at Thr172 of the alpha-subunit, e.g. by CaMKKbeta or LBK1, dephosphorylation by phosphatase PP2C | Homo sapiens |
phosphoprotein | activating phosphorylation of AMPK at Thr172 of the alpha-subunit, e.g. by CaMKKbeta or LBK1, dephosphorylation by phosphatase PP2C | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipocyte | - |
Mus musculus | - |
adipocyte | - |
Homo sapiens | - |
adipocyte | - |
Rattus norvegicus | - |
heart | - |
Mus musculus | - |
heart | - |
Homo sapiens | - |
heart | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | AMPK regulates the energy balance both at the cellular and whole body level, disorders of it are obesity, type 2 diabetes and the metabolic syndrome, overview. Activating mutations in AMPK can cause heart disease. AMPK is regulated by the AMP/ATP ratio and upstream kinases, e.g. CaMKKbeta and LBK1, overview. AMPK activation inhibits activation of the mammalian target-of-rapamycin pathway by the insulin/insulin-like growth factor-1 pathway, probably via phosphorylation of TSC2, an upstream regulator of mTOR | Mus musculus | ? | - |
? | |
additional information | AMPK regulates the energy balance both at the cellular and whole body level, disorders of it are obesity, type 2 diabetes and the metabolic syndrome, overview. Activating mutations in AMPK can cause heart disease. AMPK is regulated by the AMP/ATP ratio and upstream kinases, e.g. CaMKKbeta and LBK1, overview. AMPK activation inhibits activation of the mammalian target-of-rapamycin pathway by the insulin/insulin-like growth factor-1 pathway, probably via phosphorylation of TSC2, an upstream regulator of mTOR | Homo sapiens | ? | - |
? | |
additional information | AMPK regulates the energy balance both at the cellular and whole body level, disorders of it are obesity, type 2 diabetes and the metabolic syndrome, overview. Activating mutations in AMPK can cause heart disease. AMPK is regulated by the AMP/ATP ratio and upstream kinases, e.g. CaMKKbeta and LBK1, overview. AMPK activation inhibits activation of the mammalian target-of-rapamycin pathway by the insulin/insulin-like growth factor-1 pathway, probably via phosphorylation of TSC2, an upstream regulator of mTOR | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
trimer | AMPK exists as heterotrimeric complexes comprising catalytic alpha subunits and regulatory beta and gamma subunits | Drosophila melanogaster |
trimer | AMPK exists as heterotrimeric complexes comprising catalytic alpha subunits and regulatory beta and gamma subunits | Saccharomyces cerevisiae |
trimer | AMPK exists as heterotrimeric complexes comprising catalytic alpha subunits and regulatory beta and gamma subunits | Arabidopsis thaliana |
trimer | AMPK exists as heterotrimeric complexes comprising catalytic alpha subunits and regulatory beta and gamma subunits | Giardia intestinalis |
trimer | AMPK exists as heterotrimeric complexes comprising catalytic alpha subunits and regulatory beta and gamma subunits | Trypanosoma brucei |
trimer | AMPK exists as heterotrimeric complexes comprising catalytic alpha subunits and regulatory beta and gamma subunits | Dictyostelium discoideum |
trimer | AMPK exists as heterotrimeric complexes comprising catalytic alpha subunits and regulatory beta and gamma subunits | Schizosaccharomyces pombe |
trimer | AMPK exists as heterotrimeric complexes comprising catalytic alpha subunits and regulatory beta and gamma subunits | Caenorhabditis elegans |
trimer | AMPK exists as heterotrimeric complexes comprising catalytic alpha subunits and regulatory beta and gamma subunits | Physcomitrium patens |
trimer | AMPK exists as heterotrimeric complexes comprising catalytic alpha subunits and regulatory beta and gamma subunits, with multiple genes encoding each subunit in mammals, alpha1, alpha2, beta1, beta2, gamma1, gamma2, gamma3 | Mus musculus |
trimer | AMPK exists as heterotrimeric complexes comprising catalytic alpha subunits and regulatory beta and gamma subunits, with multiple genes encoding each subunit in mammals, alpha1, alpha2, beta1, beta2, gamma1, gamma2, gamma3 | Homo sapiens |
trimer | AMPK exists as heterotrimeric complexes comprising catalytic alpha subunits and regulatory beta and gamma subunits, with multiple genes encoding each subunit in mammals, alpha1, alpha2, beta1, beta2, gamma1, gamma2, gamma3 | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
AMP-activated protein kinase | - |
Drosophila melanogaster |
AMP-activated protein kinase | - |
Mus musculus |
AMP-activated protein kinase | - |
Homo sapiens |
AMP-activated protein kinase | - |
Rattus norvegicus |
AMP-activated protein kinase | - |
Saccharomyces cerevisiae |
AMP-activated protein kinase | - |
Arabidopsis thaliana |
AMP-activated protein kinase | - |
Giardia intestinalis |
AMP-activated protein kinase | - |
Trypanosoma brucei |
AMP-activated protein kinase | - |
Dictyostelium discoideum |
AMP-activated protein kinase | - |
Schizosaccharomyces pombe |
AMP-activated protein kinase | - |
Caenorhabditis elegans |
AMP-activated protein kinase | - |
Physcomitrium patens |
AMPK | - |
Drosophila melanogaster |
AMPK | - |
Mus musculus |
AMPK | - |
Homo sapiens |
AMPK | - |
Rattus norvegicus |
AMPK | - |
Saccharomyces cerevisiae |
AMPK | - |
Arabidopsis thaliana |
AMPK | - |
Giardia intestinalis |
AMPK | - |
Trypanosoma brucei |
AMPK | - |
Dictyostelium discoideum |
AMPK | - |
Schizosaccharomyces pombe |
AMPK | - |
Caenorhabditis elegans |
AMPK | - |
Physcomitrium patens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Drosophila melanogaster | |
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens | |
ATP | - |
Rattus norvegicus | |
ATP | - |
Saccharomyces cerevisiae | |
ATP | - |
Arabidopsis thaliana | |
ATP | - |
Giardia intestinalis | |
ATP | - |
Trypanosoma brucei | |
ATP | - |
Dictyostelium discoideum | |
ATP | - |
Schizosaccharomyces pombe | |
ATP | - |
Caenorhabditis elegans | |
ATP | - |
Physcomitrium patens |