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Literature summary for 2.7.11.31 extracted from
- 5-AMP-activated protein kinase signaling in Caenorhabditis elegans (2008), Exp. Biol. Med., 233, 12-20.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | AMPK is activated by phosphorylation through upstream kinases and 5'-AMP in response to various nutritional and stress signals | Caenorhabditis elegans |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| subunit sequence comparisons and phylogenetic trees, overview | Caenorhabditis elegans |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [acetyl-CoA carboxylase] | Caenorhabditis elegans | inhibition of acetyl-CoA carboxylase | ADP + [acetyl-CoA carboxylase] phosphate | - |
? |  |
| ATP + [HMG-CoA reductase] | Caenorhabditis elegans | inhibition of HMG-CoA carboxylase | ADP + [HMG-CoA reductase] phosphate | - |
? | |
| additional information | Caenorhabditis elegans | AMPK promotes ATP production and inhibits ATp consumption acting as a metabolic switch, mechanism, overview. AMPK is activated by phosphorylation through upstream kinases and 5'-AMP in response to various nutritional and stress signals, AMPK signaling pathways, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Caenorhabditis elegans | - |
two alpha, two beta, and five gamma gene orthologues encoding the subunit variants | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | AMPK is activated by phosphorylation through upstream kinases and 5'-AMP in response to various nutritional and stress signals | Caenorhabditis elegans |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [acetyl-CoA carboxylase] | - |
Caenorhabditis elegans | ADP + [acetyl-CoA carboxylase] phosphate | - |
? | |
| ATP + [acetyl-CoA carboxylase] | inhibition of acetyl-CoA carboxylase | Caenorhabditis elegans | ADP + [acetyl-CoA carboxylase] phosphate | - |
? | |
| ATP + [HMG-CoA reductase] | - |
Caenorhabditis elegans | ADP + [HMG-CoA reductase] phosphate | - |
? | |
| ATP + [HMG-CoA reductase] | inhibition of HMG-CoA carboxylase | Caenorhabditis elegans | ADP + [HMG-CoA reductase] phosphate | - |
? | |
| additional information | AMPK promotes ATP production and inhibits ATp consumption acting as a metabolic switch, mechanism, overview. AMPK is activated by phosphorylation through upstream kinases and 5'-AMP in response to various nutritional and stress signals, AMPK signaling pathways, overview | Caenorhabditis elegans | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| trimer | alphabetagamma heterotrimer | Caenorhabditis elegans |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 5-AMP-activated protein kinase | - |
Caenorhabditis elegans |
| AMPK | - |
Caenorhabditis elegans |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| AMP | dependent on, AMPK is activated by phosphorylation through upstream kinases and 5'-AMP in response to various nutritional and stress signals | Caenorhabditis elegans | |
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