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Literature summary for 2.7.11.31 extracted from

  • Robertson, T.P.; Mustard, K.J.; Lewis, T.H.; Clark, J.H.; Wyatt, C.N.; Blanco, E.A.; Peers, C.; Hardie, D.G.; Evans, A.M.
    AMP-activated protein kinase and hypoxic pulmonary vasoconstriction (2008), Eur. J. Pharmacol., 595, 39-43.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
5-aminoimidazole-4-carboxamide riboside i.e. AICAR, a specific AMPK activator Rattus norvegicus
AMP
-
 Rattus norvegicus
compound C inhibits AMPK and phase II, but not phase I, of hypoxic pulmonary vasoconstriction Rattus norvegicus
additional information phosphorylation of AMPK at Thr172 of the alpha-subunit activates the enzyme Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [acetyl-CoA carboxylase] Rattus norvegicus phosphorylation at Ser79 ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
additional information Rattus norvegicus hypoxic pulmonary vasoconstriction is precipitated, at least in part, by the inhibition of mitochondrial oxidative phosphorylation by hypoxia, an increase in the AMP/ATP ratio and consequent activation of AMP-activated protein kinase, mechanism, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male sprague-dawley rats
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of AMPK at Thr172 of the alpha-subunit Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
artery intrapulmonary smooth muscle Rattus norvegicus
-
lung pulmonary arterial smooth muscle Rattus norvegicus
-
smooth muscle pulmonary arterial Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [acetyl-CoA carboxylase] phosphorylation at Ser79 Rattus norvegicus ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
additional information hypoxic pulmonary vasoconstriction is precipitated, at least in part, by the inhibition of mitochondrial oxidative phosphorylation by hypoxia, an increase in the AMP/ATP ratio and consequent activation of AMP-activated protein kinase, mechanism, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Rattus norvegicus
AMPK
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus