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Literature summary for 2.7.11.31 extracted from
- AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function (2008), Eur. J. Immunol., 38, 948-956.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| AMP | - |
Mus musculus |  |
| Calmodulin | AMPK activation by phosphorylation through the Ca2+-calmodulin dependent protein kinase kinase, CaMKK | Mus musculus | |
| additional information | T cell receptor stimulation activates AMPK due to energy needs in case of cell division having regulatory function, overview. AMPK activation by phosphorylation through the Ca2+-calmodulin dependent protein kinase kinase, CaMKK | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| AMPK is phylogenetically conserved | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of AMPKalpha1-KO mice, which show a splenomegaly possibly due to the massive amplification of erythroid nucleated cells, AMPKalpha1-KO mice are fully immunocompetent in vivo and display normal cell proliferation, humoral, cytotoxic and delayed-type hypersensitivity responses following antigen injection, phenotype, overview. AMPKalpha1-KO cells display increasing sensitivity to energetic stress in vitro, and are unable to maintain adequate ATP levels in response to ATP synthase inhibition, but the cells are able to respond to antigen stimulation in vitro, overview | Mus musculus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | AMPK activation by phosphorylation through the Ca2+-calmodulin dependent protein kinase kinase, CaMKK | Mus musculus | |
| Mg2+ | - |
Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | AMP-activated protein kinase acts as an energy sensor able to adapt cellular metabolism in response to nutritional environmental variations, and it regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
wild-type C57BL/6 mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
| lymphocyte | selective expression of the AMPKalpha1 catalytic subunit in lymphoid cells | Mus musculus | - |
| splenocyte | - |
Mus musculus | - |
| thymus | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | AMP-activated protein kinase acts as an energy sensor able to adapt cellular metabolism in response to nutritional environmental variations, and it regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function, overview | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AMP-activated protein kinase | - |
Mus musculus |
| AMPK | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
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