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Literature summary for 2.7.11.31 extracted from

  • Osler, M.E.; Zierath, J.R.
    Adenosine 5-monophosphate-activated protein kinase regulation of fatty acid oxidation in skeletal muscle (2008), Endocrinology, 149, 935-941.
    View publication on PubMed
Search for more literature for 2.7.11.31

Protein Variants

Protein Variants Comment Organism
R225W naturally occuring mutation of the gamma3 subunit, which leads to a 2fold increased AMPK activity, a 90% increase in skeletal muscle glycogen content and a 30% decrease in triglycerides Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens AMPK signaling influences glucose and lipid metabolisms, mitochondrial biogenesis, and gene transcription, playing a role in trained and obese physiological state, overview. AMPK is important in the molecular regulation of lipid oxidation in skeletal muscle and the energy balance through suppression of ATP-consuming anabolic pathways and enhancement of ATP-producing catabolic pathways, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle different isozymes in muscles by different combinations of subunits, i.e. alpha1/beta2/gamma1, alpha2/beta2/gamma1, and alpha2/beta2/gamma3, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information AMPK signaling influences glucose and lipid metabolisms, mitochondrial biogenesis, and gene transcription, playing a role in trained and obese physiological state, overview. AMPK is important in the molecular regulation of lipid oxidation in skeletal muscle and the energy balance through suppression of ATP-consuming anabolic pathways and enhancement of ATP-producing catabolic pathways, overview Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
trimer different heterotrimers resulting in different isozymes, the alphabetagamma composition can be formed by two different alpha subunit variants, two different beta and three different gamma subunits, overview Homo sapiens

Synonyms

Synonyms Comment Organism
adenosine 5-monophosphate-activated protein kinase
-
 Homo sapiens
AMP-activated protein kinase
-
 Homo sapiens
AMPK
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens