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Literature summary for 2.7.11.31 extracted from

  • McGee, S.L.; van Denderen, B.J.; Howlett, K.F.; Mollica, J.; Schertzer, J.D.; Kemp, B.E.; Hargreaves, M.
    AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5 (2008), Diabetes, 57, 860-867.
    View publication on PubMed
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside i.e. AICAR Homo sapiens
AMP
-
 Homo sapiens
additional information the enzyme is activated by phosphorylation at Thr172 in the alpha subunit activation T-loop Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
transient expression of wild-type and mutant enzymes in COS-7 cells, co-expression with histone deacetylase 5 Homo sapiens

Protein Variants

Protein Variants Comment Organism
K45R a dominant negative AMPK mutant Homo sapiens
T172D a constitutively active AMPK mutant Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [histone deacetylase 5] Homo sapiens AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5 ADP + [histone deacetylase 5] phosphate
-
 ?
additional information Homo sapiens AMPK is activated in response to changes in the cellular energy charge and cellular stress via increases in the ATP-to-AMP ratio ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme is activated by phosphorylation at Thr172 in the alpha subunit activation T-loop Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
myotube primary Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [histone deacetylase 5] AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5 Homo sapiens ADP + [histone deacetylase 5] phosphate
-
 ?
ATP + [histone deacetylase 5] phosphorylation at Ser259 and Ser498 Homo sapiens ADP + [histone deacetylase 5] phosphate
-
 ?
additional information AMPK is activated in response to changes in the cellular energy charge and cellular stress via increases in the ATP-to-AMP ratio Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
trimer alphabetagamma heterotrimer composed of different alpha, beta, and gamma subunit variants Homo sapiens

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Homo sapiens
AMPK
-
 Homo sapiens
HDAC5 kinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens