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Literature summary for 2.7.11.31 extracted from

  • Gybina, A.A.; Prohaska, J.R.
    Copper deficiency results in AMP-activated protein kinase activation and acetyl-CoA carboxylase phosphorylation in rat cerebellum (2008), Brain Res., 1204, 69-76.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
AMP
-
 Rattus norvegicus
additional information phosphorylation of AMPK at Thr172 of the alpha-subunit activates the enzyme, copper deficiency results in AMP-activated protein kinase activation and acetyl-CoA carboxylase phosphorylation in rat cerebellum, overview Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Cu2+ copper deficiency results in AMP-activated protein kinase activation and acetyl-CoA carboxylase phosphorylation in rat cerebellum, overview Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [acetyl-CoA carboxylase] Rattus norvegicus copper deficiency results in AMP-activated protein kinase activation and acetyl-CoA carboxylase phosphorylation in rat cerebellum, overview ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
additional information Rattus norvegicus AMPK is a cellular energy sensor that is activated during mitochondrial inhibition and shuts down biosynthetic processes to help conserve cellular ATP levels ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of AMPK at Thr172 of the alpha-subunit Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
cerebellum
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [acetyl-CoA carboxylase] phosphorylation at Ser79 Rattus norvegicus ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
ATP + [acetyl-CoA carboxylase] copper deficiency results in AMP-activated protein kinase activation and acetyl-CoA carboxylase phosphorylation in rat cerebellum, overview Rattus norvegicus ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
additional information AMPK is a cellular energy sensor that is activated during mitochondrial inhibition and shuts down biosynthetic processes to help conserve cellular ATP levels Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Rattus norvegicus
AMPK
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus