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Literature summary for 2.7.11.31 extracted from

  • Li, X.; Han, Y.; Pang, W.; Li, C.; Xie, X.; Shyy, J.Y.; Zhu, Y.
    AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells (2008), Arterioscler. Thromb. Vasc. Biol., 28, 1789-1795.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside i.e. AICAR Homo sapiens
AMP
-
 Homo sapiens
lovastatin increases AMPK phosphorylation /activation Homo sapiens
vascular endothelial growth factor activates AMPK in endothelial progenitor cells by phosphorylation at Ser172 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
compound C i.e. dorsomorphin or 6-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [acetyl-CoA carboxylase] Homo sapiens
-
 ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
ATP + [endothelial nitric oxide synthase] Homo sapiens AMPK-eNOS signalling, overview ADP + [endothelial nitric oxide synthase] phosphate
-
 ?
additional information Homo sapiens lovostatin-induced endothelial progenitor cell to endothelial cell differentiation depends on AMPK, AMPK enhances the vasculogensis and angiogenesis of endothelial progenitor cells, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial progenitor cell from cord blood Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [acetyl-CoA carboxylase]
-
 Homo sapiens ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
ATP + [acetyl-CoA carboxylase] phosphorylation at Ser79 Homo sapiens ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
ATP + [endothelial nitric oxide synthase] AMPK-eNOS signalling, overview Homo sapiens ADP + [endothelial nitric oxide synthase] phosphate
-
 ?
ATP + [endothelial nitric oxide synthase] phosphorylation at Ser1177 Homo sapiens ADP + [endothelial nitric oxide synthase] phosphate
-
 ?
additional information lovostatin-induced endothelial progenitor cell to endothelial cell differentiation depends on AMPK, AMPK enhances the vasculogensis and angiogenesis of endothelial progenitor cells, overview Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
trimer heterotrimeric AMPK consists of a catalytic alpha subunit, and regulatory beta and gamma subunits Homo sapiens

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Homo sapiens
AMPK
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens