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Literature summary for 2.7.11.31 extracted from

  • Mukhtar, M.H.; Payne, V.A.; Arden, C.; Harbottle, A.; Khan, S.; Lange, A.J.; Agius, L.
    Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (2008), Am. J. Physiol. Regul. Integr. Comp. Physiol., 294, R766-R774.
    View publication on PubMed
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside i.e. AICAR, activates the phosphorylation of peptide QKFQRELSTKWVLN 4fold, kinetics, overview Rattus norvegicus
AMP
-
 Rattus norvegicus
metformin
-
 Rattus norvegicus

Application

Application Comment Organism
pharmacology selective AMPK activators are potential therapeutics in type 2 diabetes Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information AMPK deficiency leads to ATP depletion in hepatocytes Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.055
-
 peptide SAMS
-
 Rattus norvegicus
0.101
-
 peptide QKFQRELSTKWVLN
-
 Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [glucose hexokinase regulatory protein] Rattus norvegicus
-
 ADP + [glucose hexokinase regulatory protein] phosphate
-
 ?
additional information Rattus norvegicus AMPK inhibits hepatioc lipogenesis through multisite control, involving inhibition of glucose hexokinase translocation with consequent inhibition of flux through glucose phosphorylation and glycolysis, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + peptide SAMS
-
 Rattus norvegicus ADP + phosphorylated peptide SAMS
-
 ?
ATP + [glucose hexokinase regulatory protein]
-
 Rattus norvegicus ADP + [glucose hexokinase regulatory protein] phosphate
-
 ?
ATP + [glucose hexokinase regulatory protein] phosphorylation by AMPK at a site in residues 474-487 Rattus norvegicus ADP + [glucose hexokinase regulatory protein] phosphate
-
 ?
ATP + [peptide QKFQRELSTKWVLN] a peptide derived from glucose hexokinase regulatory protein, residues 474-487 Rattus norvegicus ADP + [peptide QKFQRELSTKWVLN] phosphate
-
 ?
ATP + [peptide SAMS]
-
 Rattus norvegicus ADP + [peptide SAMS] phosphate
-
 ?
additional information AMPK inhibits hepatioc lipogenesis through multisite control, involving inhibition of glucose hexokinase translocation with consequent inhibition of flux through glucose phosphorylation and glycolysis, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Rattus norvegicus
AMPK
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus