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Literature summary for 2.7.11.31 extracted from
- Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398 (2004), J. Biol. Chem., 279, 12220-12231.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 5-amino-4-imidazolecarboxamide riboside | - |
Homo sapiens |  |
| cAMP | dependent on, stimulates | Homo sapiens | |
| additional information | ATP depletion activates the enzyme | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + eukaryotic elongation factor 2 kinase | Homo sapiens | phosphorylation at Ser398, the enzyme plays a regulatory role in eEF2 kinase activity, overview | ADP + phosphorylated eukaryotic elongation factor 2 kinase | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| from KB cells by several steps including immunoprecipitation | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| KB cell | oral epidermoid carcinoma cell line | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + eukaryotic elongation factor 2 kinase | phosphorylation at Ser398, the enzyme plays a regulatory role in eEF2 kinase activity, overview | Homo sapiens | ADP + phosphorylated eukaryotic elongation factor 2 kinase | - |
? | |
| ATP + eukaryotic elongation factor 2 kinase | phosphorylation at Ser398 activates the eukaryotic elongation factor 2 kinase, no activity with the substrate mutant S398A | Homo sapiens | ADP + phosphorylated eukaryotic elongation factor 2 kinase | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AMP-activated protein kinase | - |
Homo sapiens |
| AMPK | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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