Activating Compound | Comment | Organism | Structure |
---|---|---|---|
5-aminoimidazole-4-carboxamide riboside | stimulation of activating AMPK phosphorylation at Thr172 | Rattus norvegicus | |
calyculin A | stimulation of activating AMPK phosphorylation at Thr172, independent of narigin | Rattus norvegicus | |
cantharidin | stimulation of activating AMPK phosphorylation at Thr172, independent of narigin | Rattus norvegicus | |
microcystin-LR | stimulation of activating AMPK phosphorylation at Thr172 | Rattus norvegicus | |
additional information | stimulation by protein phosphatase-inhibitory toxins | Rattus norvegicus | |
okadaic acid | stimulation of activating AMPK phosphorylation at Thr172, activation is antagonized by naringin | Rattus norvegicus | |
tautomycin | stimulation of activating AMPK phosphorylation at Thr172, independent of narigin | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
naringin | inhibits enzyme phosphorylation | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | AMPK regulation, AMPK mediates the autophagy suppression of okadaic acid and other protein phosphatase-inhibitory toxins, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | the enzyme is activated by phosphorylation at Thr172, which is inhibited by naringin | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
autophagic activity under different conditions | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acetyl-CoA carboxylase | phosphorylation at Ser79 | Rattus norvegicus | ADP + phosphorylated acetyl-CoA carboxylase | - |
? | |
additional information | AMPK regulation, AMPK mediates the autophagy suppression of okadaic acid and other protein phosphatase-inhibitory toxins, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AMP-activated protein kinase | - |
Rattus norvegicus |
AMPK | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |