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Literature summary for 2.7.11.31 extracted from

  • Samari, H.R.; Moeller, M.T.N.; Holden, L.; Asmyhr, T.; Seglen, P.O.
    Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophygy-suppressive toxins (2005), Biochem. J., 386, 237-244.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
5-aminoimidazole-4-carboxamide riboside stimulation of activating AMPK phosphorylation at Thr172 Rattus norvegicus
calyculin A stimulation of activating AMPK phosphorylation at Thr172, independent of narigin Rattus norvegicus
cantharidin stimulation of activating AMPK phosphorylation at Thr172, independent of narigin Rattus norvegicus
microcystin-LR stimulation of activating AMPK phosphorylation at Thr172 Rattus norvegicus
additional information stimulation by protein phosphatase-inhibitory toxins Rattus norvegicus
okadaic acid stimulation of activating AMPK phosphorylation at Thr172, activation is antagonized by naringin Rattus norvegicus
tautomycin stimulation of activating AMPK phosphorylation at Thr172, independent of narigin Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
naringin inhibits enzyme phosphorylation Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus AMPK regulation, AMPK mediates the autophagy suppression of okadaic acid and other protein phosphatase-inhibitory toxins, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme is activated by phosphorylation at Thr172, which is inhibited by naringin Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
autophagic activity under different conditions Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA carboxylase phosphorylation at Ser79 Rattus norvegicus ADP + phosphorylated acetyl-CoA carboxylase
-
?
additional information AMPK regulation, AMPK mediates the autophagy suppression of okadaic acid and other protein phosphatase-inhibitory toxins, overview Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
Rattus norvegicus
AMPK
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus