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Literature summary for 2.7.11.31 extracted from

  • Ferrer, A.; Caelles, C.; Massot, N.; Hegardt, F.G.
    Allosteric activation of rat liver microsomal [hydroxymethylglutaryl-CoA reductase (NADPH)]kinase by nucleoside phosphates (1987), Biol. Chem. Hoppe-Seyler, 368, 249-257.
    View publication on PubMed
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
3'-AMP
-
 Rattus norvegicus
5'-AMP
-
 Rattus norvegicus
adenosine
-
 Rattus norvegicus
ADP
-
 Rattus norvegicus
cAMP
-
 Rattus norvegicus
CDP allosteric activator Rattus norvegicus
CMP
-
 Rattus norvegicus
D-ribose 5-phosphate
-
 Rattus norvegicus
GMP
-
 Rattus norvegicus
IDP
-
 Rattus norvegicus
IMP
-
 Rattus norvegicus
UDP allosteric activator Rattus norvegicus
UMP
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by adenosine-5'-pentaphospho-5'-adenosine Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.295
-
 ATP pH 7.5, 37°C Rattus norvegicus
0.315
-
 ATP pH 7.5, 37°C, in presence of AMP Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-
microsome
-
 Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] Rattus norvegicus inactivates EC 1.1.1.34 by phosphorylation ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)]
-
 Rattus norvegicus ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
-
 ?
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] inactivates EC 1.1.1.34 by phosphorylation Rattus norvegicus ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
-
 ?
CTP + [hydroxymethylglutaryl-CoA reductase (NADPH)]
-
 Rattus norvegicus CDP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
-
 ?
GTP + [hydroxymethylglutaryl-CoA reductase (NADPH)]
-
 Rattus norvegicus GDP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
-
 ?
ITP + [hydroxymethylglutaryl-CoA reductase (NADPH)]
-
 Rattus norvegicus IDP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
-
 ?
additional information protein kinase C and Ca2+/calmodulin dependent reductase kinases are no substrates Rattus norvegicus ?
-
 ?
UTP + [hydroxymethylglutaryl-CoA reductase (NADPH)]
-
 Rattus norvegicus UDP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
-
 ?

Cofactor

Cofactor Comment Organism Structure
2'-dAMP activation, can replace AMP or ADP Rattus norvegicus