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Literature summary for 2.7.11.31 extracted from
- Allosteric activation of rat liver cytosolic 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase by nucleoside diphosphates (1984), J. Biol. Chem., 259, 2810-2815.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ADP | requirement | Rattus norvegicus |  |
| alpha,beta-methylene-ADP | allosteric activator, can replace ADP, with 66% efficiency with bovine serum albumin as substrate | Rattus norvegicus | |
| CDP | allosteric activator | Rattus norvegicus | |
| additional information | not activated by cAMP | Rattus norvegicus | |
| UDP | allosteric activator | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.14 | - |
ATP | pH 7.5, 37°C | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 56000 | - |
x * 56000, SDS-PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | Rattus norvegicus | inactivates EC 1.1.1.34 by phosphorylation | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
3.130 nU/mg | Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -196°C, stored in liquid nitrogen, stable for several months | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + bovine serum albumin | fraction V | Rattus norvegicus | ADP + [bovine serum albumin] phosphate | - |
? | |
| ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | - |
Rattus norvegicus | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
| ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | inactivates EC 1.1.1.34 by phosphorylation | Rattus norvegicus | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
| dATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | phosphorylation at about 90% the rate of ATP | Rattus norvegicus | dADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
| GTP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | phosphorylation at about 30% the rate of ATP | Rattus norvegicus | GDP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
| ITP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | phosphorylation at about 10% the rate of ATP | Rattus norvegicus | IDP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
| UTP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | phosphorylation at about 5% the rate of ATP | Rattus norvegicus | UDP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 56000, SDS-PAGE | Rattus norvegicus |
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