Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ADP | requirement | Rattus norvegicus | |
alpha,beta-methylene-ADP | allosteric activator, can replace ADP, with 66% efficiency with bovine serum albumin as substrate | Rattus norvegicus | |
CDP | allosteric activator | Rattus norvegicus | |
additional information | not activated by cAMP | Rattus norvegicus | |
UDP | allosteric activator | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.14 | - |
ATP | pH 7.5, 37°C | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
56000 | - |
x * 56000, SDS-PAGE | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | Rattus norvegicus | inactivates EC 1.1.1.34 by phosphorylation | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
3.130 nU/mg | Rattus norvegicus |
Storage Stability | Organism |
---|---|
-196°C, stored in liquid nitrogen, stable for several months | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + bovine serum albumin | fraction V | Rattus norvegicus | ADP + [bovine serum albumin] phosphate | - |
? | |
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | - |
Rattus norvegicus | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | inactivates EC 1.1.1.34 by phosphorylation | Rattus norvegicus | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
dATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | phosphorylation at about 90% the rate of ATP | Rattus norvegicus | dADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
GTP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | phosphorylation at about 30% the rate of ATP | Rattus norvegicus | GDP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
ITP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | phosphorylation at about 10% the rate of ATP | Rattus norvegicus | IDP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
UTP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | phosphorylation at about 5% the rate of ATP | Rattus norvegicus | UDP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 56000, SDS-PAGE | Rattus norvegicus |