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Literature summary for 2.7.11.30 extracted from

  • Mahmoud, M.; Borthwick, G.M.; Hislop, A.A.; Arthur, H.M.
    Endoglin and activin receptor-like-kinase 1 are co-expressed in the distal vessels of the lung: implications for two familial vascular dysplasias, HHT and PAH (2009), Lab. Invest., 89, 15-25.
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Mus musculus
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 wild-type and endoglin +/- mice
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Source Tissue

Source Tissue Comment Organism Textmining
artery
-
 Mus musculus
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blood vessel
-
 Mus musculus
-
lung
-
 Mus musculus
-
vascular endothelial cell
-
 Mus musculus
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vasculature
-
 Mus musculus
-
vein
-
 Mus musculus
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Synonyms

Synonyms Comment Organism
activin receptor-like-kinase 1
-
 Mus musculus
ACVRL1
-
 Mus musculus
ALK1
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus in endoglin +/- mice, ACVRL1 is expressed in small regions of the distal arteries where endoglin is below detectable limits, co-expression of ACVRL1 and endoglin and associated pSmad1/5/8 signalling in the endothelial cells of distal arterioles additional information

General Information

General Information Comment Organism
malfunction association of ACVRL1 mutations with a vascular disease, familial pulmonary artery hypertension Mus musculus
physiological function activin receptor-like-kinase 1 is a receptor for ligands of the transforming growth factor-beta family Mus musculus