Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [TGF-beta receptor I] | Homo sapiens | TGF-beta signalling pathway regulation, overview | ADP + [TGF-beta receptor I] phosphate | - |
? | |
additional information | Homo sapiens | signaling by RON, a phosphotyrosine kinase receptor, cooperates with Smad4-independent TGF-beta signaling to promote cell motility and invasion, knocking down RON expression in Smad4-deficient cells suppresses TGF-beta-mediated motility and invasion. Functional inactivation by site-directed mutations of two Smad binding sites on the RON promoter inhibits TGF-beta-mediated repression of RON promoter activity, cross-talk of Smad4-independent TGF-beta signaling and the RON pathway promotes an invasive phenotype, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
AsPC-1 cell | - |
Homo sapiens | - |
BxPC-3 cell | - |
Homo sapiens | - |
CAPAN-2 cell | - |
Homo sapiens | - |
CFPAC-1 cell | - |
Homo sapiens | - |
MiaPaCa-2 cell | - |
Homo sapiens | - |
PANC-1 cell | - |
Homo sapiens | - |
pancreatic ductal adenocarcinoma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [TGF-beta receptor I] | - |
Homo sapiens | ADP + [TGF-beta receptor I] phosphate | - |
? | |
ATP + [TGF-beta receptor I] | TGF-beta signalling pathway regulation, overview | Homo sapiens | ADP + [TGF-beta receptor I] phosphate | - |
? | |
additional information | signaling by RON, a phosphotyrosine kinase receptor, cooperates with Smad4-independent TGF-beta signaling to promote cell motility and invasion, knocking down RON expression in Smad4-deficient cells suppresses TGF-beta-mediated motility and invasion. Functional inactivation by site-directed mutations of two Smad binding sites on the RON promoter inhibits TGF-beta-mediated repression of RON promoter activity, cross-talk of Smad4-independent TGF-beta signaling and the RON pathway promotes an invasive phenotype, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TGF-beta type I receptor kinase | - |
Homo sapiens |
transforming growth factor-beta type 1 receptor kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |