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Literature summary for 2.7.11.30 extracted from

  • Zhou, L.; Nguyen, A.N.; Sohal, D.; Ying Ma, J.; Pahanish, P.; Gundabolu, K.; Hayman, J.; Chubak, A.; Mo, Y.; Bhagat, T.D.; Das, B.; Kapoun, A.M.; Navas, T.A.; Parmar, S.; Kambhampati, S.; Pellagatti, A.; Braunchweig, I.; Zhang, Y.; Wickrema, A.; Medicherla, S.; Boultwood, J.; Platanias, L.C.; Higgins, L.S.
    Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS (2008), Blood, 112, 3434-3443.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information knockout of TBRI by shRNA suppression using a lentiviral construct leads to decreased smad2 activtaion and reverses the suppressive effects of TGF-beta on hematopoiesis, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
SD-208 inhibition of the TBRI kinase inhibits TGF-beta-mediated smad2 activation in hematopoietic progenitors, alleviates anemia, and stimulates hematopoiesis in vivo in bone marrow Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [TGF-beta receptor I] Homo sapiens
-
ADP + [TGF-beta receptor I] phosphate
-
?
additional information Homo sapiens the TGF-beta pathway is overactivated in myelodysplastic syndrome, MDS, involving ineffective hematopoiesis leading to peripheral cytopenias. Suppression of the TGF-beta signaling leads to in vitro enhancement of hematopoiesis, overview. TBRi inhibition can improve anemia in a model of bone marrow failure, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P36897
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow CD34+ and stromal cells Homo sapiens
-
hematopoietic stem cell CD34+ Homo sapiens
-
HS-5 cell bone marrow stromal cells Homo sapiens
-
K-562 cell hematopoietic cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [TGF-beta receptor I]
-
Homo sapiens ADP + [TGF-beta receptor I] phosphate
-
?
additional information the TGF-beta pathway is overactivated in myelodysplastic syndrome, MDS, involving ineffective hematopoiesis leading to peripheral cytopenias. Suppression of the TGF-beta signaling leads to in vitro enhancement of hematopoiesis, overview. TBRi inhibition can improve anemia in a model of bone marrow failure, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
alk5 kinase
-
Homo sapiens
TBRI
-
Homo sapiens
TGF-beta receptor I kinase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens