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Literature summary for 2.7.11.30 extracted from

  • Goumans, M.J.; Valdimarsdottir, G.; Itoh, S.; Lebrin, F.; Larsson, J.; Mummery, C.; Karlsson, S.; ten Dijke, P.
    Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling (2003), Mol. Cell, 12, 817-828.
    View publication on PubMed
Search for more literature for 2.7.11.30

Activating Compound

Activating Compound Comment Organism Structure
ALK5 is important for ALK1/TGF-beta signaling Mus musculus
TGF-beta activates the type II and type I membrane receptors, e.g. ALK1 and ALK5 Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression of ALK1 and ALK5 in 293T cells, Hep-G2 cells, and in COS-7 cells using the adenovirus transfection system Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information knockdown of ALK5 expression in embryonic endothelial cells by antisense oligonucleotides results in inhibition of both TGF-beta-induced Smad 2 and Smad1/5 phosphorylation, an ALk5mutant defective in Smad activation rescues TGF-beta/ALK1-induced signaling in ALK5 null mutant endothelial cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information ALK1 mediates inhibition of the ALK5/Smad2/3 pathway Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Smad1 Mus musculus phosphorylation by ALK1 ADP + phosphorylated Smad1
-
 ?
ATP + Smad2 Mus musculus phosphorylation by ALK5 ADP + phosphorylated Smad2
-
 ?
ATP + Smad3 Mus musculus phosphorylation by ALK5 ADP + phosphorylated Smad3
-
 ?
ATP + Smad5 Mus musculus phosphorylation by ALK1 ADP + phosphorylated Smad5
-
 ?
additional information Mus musculus TGF-beta regulates the activation state of endothelium via two opposing type I receptor/Smad pathways: ALK1 induces Smad1/5 phosphorylation leading to increased endothelial cell proliferation and migration, while ALK5 promotes Smad2/3 activation and inhibits both processes, regulation overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelium embryonic cells Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Smad1 phosphorylation by ALK1 Mus musculus ADP + phosphorylated Smad1
-
 ?
ATP + Smad2 phosphorylation by ALK5 Mus musculus ADP + phosphorylated Smad2
-
 ?
ATP + Smad3 phosphorylation by ALK5 Mus musculus ADP + phosphorylated Smad3
-
 ?
ATP + Smad5 phosphorylation by ALK1 Mus musculus ADP + phosphorylated Smad5
-
 ?
additional information TGF-beta regulates the activation state of endothelium via two opposing type I receptor/Smad pathways: ALK1 induces Smad1/5 phosphorylation leading to increased endothelial cell proliferation and migration, while ALK5 promotes Smad2/3 activation and inhibits both processes, regulation overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
activin receptor-like kinase 1
-
 Mus musculus
activin receptor-like kinase 5
-
 Mus musculus
ALK1
-
 Mus musculus
ALK5
-
 Mus musculus
TbetaRI
-
 Mus musculus
TbetaRII
-
 Mus musculus
TGF-beta receptor
-
 Mus musculus
transforming growth factor-beta receptor
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus