Activating Compound | Comment | Organism | Structure |
---|---|---|---|
TGF-beta 3 | binds and activates ALK5 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
co-expression and co-localization of ALK1 mutant Q201D and cytoplasmic PEG10-RF1 mutant YFP in COS-1 cells, expression of ALK1 and ALK5 with PEG10-RF1 in a two-hydrid system in Saccharomyces cerevisiae, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
Q201D | constitutively active ALK1 mutant | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
PEG10 | ancient retroviral/retrotransposon element intergrated as a single copy gene in to human chromosome 7q21, encodes two splicing varaiants PEG10-RF1 and PEG10-RF1/2, gag- and gag-pol-like proteins that interact with TGF-beta family proteins, DNA and amino acid sequence deteramination and analysis of PEG10-RF1, PEG10-RF1 inhibits ALK1 and ALK5 signaling by direct interaction, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | with a cytoplasmic domain | Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
activin receptor-like kinase 1 | - |
Homo sapiens |
activin receptor-like kinase 5 | - |
Homo sapiens |
ALK1 | - |
Homo sapiens |
ALK5 | - |
Homo sapiens |
TGF-beta type I receptor | - |
Homo sapiens |
transforming growth factor-beta receptor | - |
Homo sapiens |