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Literature summary for 2.7.11.30 extracted from

  • Zhang, N.; Kumar, M.; Xu, G.; Ju, W.; Yoon, T.; Xu, E.; Huang, X.; Gaisano, H.; Peng, C.; Wang, Q.
    Activin receptor-like kinase 7 induces apoptosis of pancreatic beta cells and beta cell lines (2006), Diabetologia, 49, 506-518.
    View publication on PubMed
Search for more literature for 2.7.11.30

Activating Compound

Activating Compound Comment Organism Structure
actividin binds and activates the type I receptor ALK7 Rattus norvegicus
additional information increased D-glucose and palmitate concentrations increase the ALK7 enzyme expression in INS-1 cells Rattus norvegicus
TGF-beta binds and activates the TGF-family receptor kinases of type I and type II, e.g. type I receptor ALK7 Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expression of ALK7 in COS cells, native expression analysis of ALK7 in different cells types Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane with a large cytoplasmic domain Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Smad2 Rattus norvegicus ALK7 is involved in regulation of cell proliferation and apoptosis, regulation, overview ADP + phosphorylated Smad2
-
 ?
ATP + Smad3 Rattus norvegicus ALK7 ADP + phosphorylated Smad3
-
 ?
additional information Rattus norvegicus ALK7 induces apoptosis of pancreatic beta cells and beta cell lines via Smad2-caspase3 pathways causing diabetes of type 1 and 2, ALK7 activation suppresses Akt activation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
additional information expression analysis of ALK7 in different cells types, overview Rattus norvegicus
-
pancreas
-
 Rattus norvegicus
-
pancreatic beta cell
-
 Rattus norvegicus
-
pancreatic islet
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Smad2 ALK7 Rattus norvegicus ADP + phosphorylated Smad2
-
 ?
ATP + Smad2 ALK7 is involved in regulation of cell proliferation and apoptosis, regulation, overview Rattus norvegicus ADP + phosphorylated Smad2
-
 ?
ATP + Smad3 ALK7 Rattus norvegicus ADP + phosphorylated Smad3
-
 ?
additional information ALK7 induces apoptosis of pancreatic beta cells and beta cell lines via Smad2-caspase3 pathways causing diabetes of type 1 and 2, ALK7 activation suppresses Akt activation Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 55000-72000, different cell sources, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
activin receptor-like kinase 7
-
 Rattus norvegicus
ALK7
-
 Rattus norvegicus
More the enzyme belongs to the TGF-beta superfamily of enzymes Rattus norvegicus
type I serine/threonine kinase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus