Activating Compound | Comment | Organism | Structure |
---|---|---|---|
TGF-beta | - |
Mus musculus | |
TGF-beta | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of His-tagged transforming growth factor-beta type I receptor kinase domain mutant T204D in Spodoptera frugiperda Sf9 cells using the baculovirus infection system | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4(quinolin-4-yl)-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole derivatives | IC50 of 0.00005-0.0013 mM | Homo sapiens | |
4(quinolin-4-yl)-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole derivatives | IC50 of 0.00015-0.0051 mM, overview | Mus musculus | |
4-phenyl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole derivatives | IC50 of 0.000005-0.0195 mM | Homo sapiens | |
4-phenyl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole derivatives | IC50 of 0.00011-0.020 mM, overview | Mus musculus | |
LY364947 | IC50 is 51 nM | Homo sapiens | |
LY364947 | IC50 is 31 nM | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | the enzyme is involved in p38 MAPK activation | ? | - |
? | |
additional information | Homo sapiens | the enzyme is involved in p38 MAPK activation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant His-tagged transforming growth factor-beta type I receptor kinase domain mutant T204D from insect Sf9 cells by nickel affinity chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Mus musculus | - |
NIH-3T3 cell | fibroblast cell line | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is involved in p38 MAPK activation | Mus musculus | ? | - |
? | |
additional information | the enzyme is involved in p38 MAPK activation | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TbetaR-I | - |
Mus musculus |
TbetaR-I | - |
Homo sapiens |
TGF-beta type I receptor kinase | - |
Mus musculus |
TGF-beta type I receptor kinase | - |
Homo sapiens |
transforming growth factor-beta type I receptor kinase | - |
Mus musculus |
transforming growth factor-beta type I receptor kinase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mus musculus |
7.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000005 | 0.0195 | IC50 of 0.000005-0.0195 mM | Homo sapiens | 4-phenyl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole derivatives | |
0.000031 | - |
IC50 is 31 nM | Mus musculus | LY364947 | |
0.00005 | 0.0013 | IC50 of 0.00005-0.0013 mM | Homo sapiens | 4(quinolin-4-yl)-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole derivatives | |
0.000051 | - |
IC50 is 51 nM | Homo sapiens | LY364947 | |
0.00011 | 0.02 | IC50 of 0.00011-0.020 mM, overview | Mus musculus | 4-phenyl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole derivatives | |
0.00015 | 0.0051 | IC50 of 0.00015-0.0051 mM, overview | Mus musculus | 4(quinolin-4-yl)-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole derivatives |