Literature summary for 2.7.11.30 extracted from

Roberts, H.J.; Hu, S.; Qiu, Q.; Leung, P.C.; Caniggia, I.; Gruslin, A.; Tsang, B.; Peng, C.
Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta (2003), Biol. Reprod., 68, 1719-1726.

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Activating Compound

Activating Compound	Comment	Organism	Structure
actividin	TGF-beta receptor I and ALK7 possess an actividin receptor-binding domain	Homo sapiens
nodal	-	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
ALK7, DNA and amino acid sequence determination and analysis, genetic organization, determination of several isoforms by alternative splicing of ALK7	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of a truncated mutant ALK7	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	transmembrane protein	Homo sapiens	16020	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8NER5	gene ACVRIC, activin receptor type 1C precursor, four GenBank entries; several isoforms by alternative splicing	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-
heart	low ALK7 expression level	Homo sapiens	-
kidney	high ALK7 expression level	Homo sapiens	-
liver	-	Homo sapiens	-
muscle	-	Homo sapiens	-
placenta	high ALK7 expression level, co-expression of nodal in different gestational stages	Homo sapiens	-
trophoblast	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
activin receptor-like kinase 7	-	Homo sapiens
ACTR-IC	-	Homo sapiens
ALK7	-	Homo sapiens
TGF-beta receptor 1	-	Homo sapiens
transforming growth factor-beta receptor 1	-	Homo sapiens

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Release 2023.1 (January 2023)