Literature summary for 2.7.11.26 extracted from

Liu, Y.H.; Wei, W.; Yin, J.; Liu, G.P.; Wang, Q.; Cao, F.Y.; Wang, J.Z.
Proteasome inhibition increases tau accumulation independent of phosphorylation (2009), Neurobiol. Aging, 30, 1949-1961.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + protein tau	Rattus norvegicus	-	ADP + protein tau phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	-	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
hippocampus	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + protein tau	-	Rattus norvegicus	ADP + protein tau phosphate	-	?

Synonyms

Synonyms	Comment	Organism
glycogen synthase kinase-3beta	-	Rattus norvegicus
GSK-3beta	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	after lactacystin treatment, the total level of GSK-3beta does not change while the Ser-9-phosphorylated GSK-3beta (inactive form) decreases, especially at 72 h	down

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Release 2023.1 (January 2023)