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Literature summary for 2.7.11.26 extracted from
- Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: role of GSK-3beta in adult brain (2009), J. Pharmacol. Sci., 109, 174-178.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| lithium | - |
Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + protein tau | - |
Mus musculus | ADP + protein tau phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glycogen synthase kinase-3beta | - |
Mus musculus |
| GSK-3beta | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | GSK-3beta heterozygote mice, which express GSK-3beta at 50% wild type levels, have impaired memory reconsolidation but normal memory consolidation | Mus musculus |
| physiological function | GSK-3beta activation is required for memory reconsolidation in the adult brain | Mus musculus |
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Release 2023.1 (January 2023)
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