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Literature summary for 2.7.11.26 extracted from

  • Espada, S.; Rojo, A.I.; Salinas, M.; Cuadrado, A.
    The muscarinic M1 receptor activates Nrf2 through a signaling cascade that involves protein kinase C and inhibition of GSK-3beta: connecting neurotransmission with neuroprotection (2009), J. Neurochem., 110, 1107-1119.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
Y216F inactive Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Protein kinase C protein kinase C inhibits GSK-3beta by phosphorylating its auto-inhibitory domain at Ser9 Rattus norvegicus
SB216763 potent and selective cell permeable ATP-competitive inhibitor of GSK3 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
-
Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3beta
-
Rattus norvegicus
GSK-3beta
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000034
-
-
Rattus norvegicus SB216763

General Information

General Information Comment Organism
malfunction inhibition of GSK-3beta mediates Nrf2 activation by the M1 receptor Rattus norvegicus