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Literature summary for 2.7.11.26 extracted from

  • Burgos-Ramos, E.; Martos-Moreno, G.A.; Lopez, M.G.; Herranz, R.; Aguado-Llera, D.; Egea, J.; Frechilla, D.; Cenarruzabeitia, E.; Leon, R.; Arilla-Ferreiro, E.; Argente, J.; Barrios, V.
    The N-terminal tripeptide of insulin-like growth factor-I protects against beta-amyloid-induced somatostatin depletion by calcium and glycogen synthase kinase 3beta modulation (2009), J. Neurochem., 109, 360-370.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
insulin-like growth factor-I
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein tau Rattus norvegicus
-
 ADP + protein tau phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein activity of GSK3beta is regulated through phosphorylation on serine-9 (inhibitory) and tyrosine-216 residues (stimulatory) Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus hippocampal neuron Rattus norvegicus
-
neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein tau
-
 Rattus norvegicus ADP + protein tau phosphate
-
 ?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase 3beta
-
 Rattus norvegicus
GSK3beta
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus