Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-bromo-indirubin-3'-oxime | - |
Mus musculus | |
LiCl | - |
Mus musculus | |
SB 216763 | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | isoform GSK-3beta | Mus musculus | 5829 | - |
nucleus | isoform GSK-3alpha | Mus musculus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | - |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mesenchymal stem cell | bone marrow-derived mesenchymal stem cell | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-catenin | substrate of isoform GSK-3beta | Mus musculus | ADP + phosphorylated beta-catenin | - |
? | |
ATP + c-Jun | substrate of isoform GSK-3alpha | Mus musculus | ADP + phosphorylated c-Jun | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycogen synthase kinase-3 | - |
Mus musculus |
GSK-3alpha | isoform | Mus musculus |
GSK-3beta | isoform | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | 5-azacytidine treatment (0.005 mM for 24 h) causes significant up-regulation of GSK-3beta whereas it stimulates GSK-3alpha expression only modestly | up |
General Information | Comment | Organism |
---|---|---|
physiological function | GSK-3 is necessary and sufficient for cardiomyocyte differentiation in mesenchymal stem cells, GSK-3beta in the cytosol induces cardiomyocyte differentiation of mesenchymal stem cells through down-regulation of beta-catenin. In contrast, GSK-3alpha in the nucleus inhibits cardiomyocyte differentiation through down-regulation of c-Jun | Mus musculus |