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Literature summary for 2.7.11.26 extracted from

  • Cho, J.; Rameshwar, P.; Sadoshima, J.
    Distinct roles of glycogen synthase kinase (GSK)-3alpha and GSK-3beta in mediating cardiomyocyte differentiation in murine bone marrow-derived mesenchymal stem cells (2009), J. Biol. Chem., 284, 36647-36658.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
6-bromo-indirubin-3'-oxime
-
Mus musculus
LiCl
-
Mus musculus
SB 216763
-
Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol isoform GSK-3beta Mus musculus 5829
-
nucleus isoform GSK-3alpha Mus musculus 5634
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
mesenchymal stem cell bone marrow-derived mesenchymal stem cell Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-catenin substrate of isoform GSK-3beta Mus musculus ADP + phosphorylated beta-catenin
-
?
ATP + c-Jun substrate of isoform GSK-3alpha Mus musculus ADP + phosphorylated c-Jun
-
?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3
-
Mus musculus
GSK-3alpha isoform Mus musculus
GSK-3beta isoform Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus 5-azacytidine treatment (0.005 mM for 24 h) causes significant up-regulation of GSK-3beta whereas it stimulates GSK-3alpha expression only modestly up

General Information

General Information Comment Organism
physiological function GSK-3 is necessary and sufficient for cardiomyocyte differentiation in mesenchymal stem cells, GSK-3beta in the cytosol induces cardiomyocyte differentiation of mesenchymal stem cells through down-regulation of beta-catenin. In contrast, GSK-3alpha in the nucleus inhibits cardiomyocyte differentiation through down-regulation of c-Jun Mus musculus