Protein Variants | Comment | Organism |
---|---|---|
K85R | dead-kinase mutant of GSK-3beta | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LiCl | complete inhibition at 2 mM | Homo sapiens | |
SB-415286 | complete inhibition at 0.005 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain stem | - |
Homo sapiens | - |
neuron | - |
Homo sapiens | - |
SH-SY5Y cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + protein tau | - |
Homo sapiens | ADP + protein tau phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycogen synthase kinase-3 | - |
Homo sapiens |
GSK-3beta | isoform | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | chronic inhibition of GSK-3 enhances glycolysis | Mus musculus |
physiological function | mitochondrial hexokinase II is a promoter of neuronal survival under the regulation of GSK-3 | Mus musculus |