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Literature summary for 2.7.11.26 extracted from

  • Xingi, E.; Smirlis, D.; Myrianthopoulos, V.; Magiatis, P.; Grant, K.M.; Meijer, L.; Mikros, E.; Skaltsounis, A.L.; Soteriadou, K.
    6-Br-5methylindirubin-3'oxime (5-Me-6-BIO) targeting the leishmanial glycogen synthase kinase-3 (GSK-3) short form affects cell-cycle progression and induces apoptosis-like death: exploitation of GSK-3 for treating leishmaniasis (2009), Int. J. Parasitol., 39, 1289-1303.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
6-bromo-5-methylindirubin-3'-oxime potent inhibitor Leishmania donovani
6-bromo-indirubin-3'-acetoxime potent inhibitor Leishmania donovani
6-bromo-indirubin-3'-oxime potent inhibitor Leishmania donovani
additional information not inhibited by indirubin, indirubin-3'-oxime, 5-bromo-indirubin, 5-aminoindirubin-3'-oxime, 6-bromo-indirubin, 6-bromo-N-methyl-indirubin-3'-oxime, 6-bromo-N-methyl-indirubin-3'-acetoxime, 6-bromo-indirubin-3'diethyl phosphatoxime, indirubin-3'-methoxime, 6-bromo-5-nitroindirubin, 6-bromo-5-nitroindirubin-3'-oxime, and 6-bromo-5-methylindirubin Leishmania donovani

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
47000
-
 SDS-PAGE Leishmania donovani

Organism

Organism UniProt Comment Textmining
Leishmania donovani
-
-
-
Leishmania donovani LG13
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amastigote
-
 Leishmania donovani
-
promastigote
-
 Leishmania donovani
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + axin
-
 Leishmania donovani ADP + phosphorylated axin
-
 ?
ATP + axin
-
 Leishmania donovani LG13 ADP + phosphorylated axin
-
 ?
ATP + casein
-
 Leishmania donovani ADP + phosphorylated casein
-
 ?
ATP + casein
-
 Leishmania donovani LG13 ADP + phosphorylated casein
-
 ?
ATP + mammalian histone H1
-
 Leishmania donovani ADP + phosphorylated mammalian histone H1
-
 ?
ATP + mammalian histone H1
-
 Leishmania donovani LG13 ADP + phosphorylated mammalian histone H1
-
 ?
ATP + myelin basic protein
-
 Leishmania donovani ADP + phosphorylated myelin basic protein
-
 ?
ATP + myelin basic protein
-
 Leishmania donovani LG13 ADP + phosphorylated myelin basic protein
-
 ?
ATP + YRRAAVPPSPSLSRHSSPHQSpEDEEE
-
 Leishmania donovani ADP + ?
-
 ?
ATP + YRRAAVPPSPSLSRHSSPHQSpEDEEE
-
 Leishmania donovani LG13 ADP + ?
-
 ?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3
-
 Leishmania donovani
GSK-3
-
 Leishmania donovani
GSK-3beta isoform Leishmania donovani

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Leishmania donovani