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Literature summary for 2.7.11.26 extracted from
- GSK-3beta, a therapeutic target for cardiomyocyte protection (2009), Circ. J., 73, 1184-1192.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| lithium chloride | - |
Rattus norvegicus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | phosphorylation of GSK-3beta at Ser9 reduces activity of this kinase | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cardiomyocyte | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + p53 | - |
Rattus norvegicus | ADP + phosphorylated p53 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glycogen synthase kinase-3beta | - |
Rattus norvegicus |
| GSK-3beta | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | GSK-3beta is a multifunctional Ser/Thr kinase that plays important roles in necrosis and apoptosis of cardiomyocytes | Rattus norvegicus |
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Release 2023.1 (January 2023)
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