Literature summary for 2.7.11.26 extracted from

Martin, L.; Magnaudeix, A.; Esclaire, F.; Yardin, C.; Terro, F.
Inhibition of glycogen synthase kinase-3beta downregulates total tau proteins in cultured neurons and its reversal by the blockade of protein phosphatase-2A (2009), Brain Res., 1252, 66-75.

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Inhibitors

Inhibitors	Comment	Organism	Structure
6-bromo-indirubin-3'-oxime	selective and potent GSK3beta inhibitor	Rattus norvegicus
LiCl	lithium is a weak inhibitor of GSK3beta, lithium dose-dependently inhibits GSK3beta through the phosphorylation of serine 9 residue	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cerebral cortical neuron	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + protein tau	-	Rattus norvegicus	ADP + protein tau phosphate	-	?

Synonyms

Synonyms	Comment	Organism
glycogen synthase kinase-3beta	-	Rattus norvegicus
GSK3beta	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	GSK3beta regulates both tau phosphorylation and total tau levels through protein phosphatase-2A	Rattus norvegicus

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Release 2023.1 (January 2023)