Literature summary for 2.7.11.26 extracted from

Kang, N.S.; Lee, G.N.; Kim, C.H.; Bae, M.A.; Kim, I.; Cho, Y.S.
Identification of small molecules that inhibit GSK-3beta through virtual screening (2009), Bioorg. Med. Chem. Lett., 19, 533-537.

Search for more literature for 2.7.11.26

Inhibitors

Inhibitors	Comment	Organism	Structure
KRM-189	74% inhibition at 0.01 mM, competes with ATP for GSK-3beta, leading to decreased Vmax and constant Km with increasing concentrations of ATP	Homo sapiens
KRM-191	84% inhibition at 0.01 mM, competes with ATP for GSK-3beta, leading to decreased Vmax and constant Km with increasing concentrations of ATP	Homo sapiens
KRM-192	75% inhibition at 0.01 mM	Homo sapiens
KRM-195	80% inhibition at 0.01 mM	Homo sapiens
KRM-296	65% inhibition at 0.01 mM	Homo sapiens
KRM-7777	65% inhibition at 0.01 mM	Homo sapiens
LiCl	71% inhibition at 0.01 mM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P49841	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + beta-catenin	-	Homo sapiens	ADP + beta-catenin phosphate	-	?

Synonyms

Synonyms	Comment	Organism
glycogen synthase kinase-3beta	-	Homo sapiens
GSK-3beta	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000071	-	-	Homo sapiens	LiCl
0.000467	-	-	Homo sapiens	KRM-191
0.000539	-	-	Homo sapiens	KRM-296
0.000548	-	-	Homo sapiens	KRM-189
0.001012	-	-	Homo sapiens	KRM-192
0.001863	-	-	Homo sapiens	KRM-195
0.007149	-	-	Homo sapiens	KRM-7777

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Release 2023.1 (January 2023)