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Literature summary for 2.7.11.26 extracted from

  • Mercado-Gomez, O.; Hernandez-Fonseca, K.; Villavicencio-Queijeiro, A.; Massieu, L.; Chimal-Monroy, J.; Arias, C.
    Inhibition of Wnt and PI3K signaling modulates GSK-3beta activity and induces morphological changes in cortical neurons: role of tau phosphorylation (2008), Neurochem. Res., 33, 1599-1609.
    View publication on PubMed
Search for more literature for 2.7.11.26

Activating Compound

Activating Compound Comment Organism Structure
Dickkopf-1 100 ng/ml Rattus norvegicus
Frizzled-8 100 ng/ml Rattus norvegicus
additional information GSK-3beta is activated by inhibition of both Wnt and PI3K/Akt signaling Rattus norvegicus
Wortmannin 100 ng/ml Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
LiCl
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P18266
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
cerebral cortical neuron
-
 Rattus norvegicus
-
hippocampus
-
 Rattus norvegicus
-
primary culture
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein PHF-1 (Ser396/404)
-
 Rattus norvegicus ADP + protein PHF-1 (Ser396/404) phosphate
-
 ?
ATP + protein tau
-
 Rattus norvegicus ADP + protein tau phosphate
-
 ?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3beta
-
 Rattus norvegicus
GSK-3beta
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus