Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.26 extracted from

  • Hu, M.; Waring, J.F.; Gopalakrishnan, M.; Li, J.
    Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells (2008), J. Neurochem., 106, 1371-1377.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
beta-amyloid peptide 1-42 0.01 mM, induces phosphorylation at Tyr216 activating GSK-3beta Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
A-582941 attenuates beta-amyloid peptide 1-42-induced activation of GSK-3beta Rattus norvegicus
alpha-bungarotoxin attenuates beta-amyloid peptide 1-42-induced activation of GSK-3beta Rattus norvegicus
CHIR98023 attenuates beta-amyloid peptide 1-42-induced activation of GSK-3beta Rattus norvegicus
methyllycaconitine attenuates beta-amyloid peptide 1-42-induced activation of GSK-3beta Rattus norvegicus
Nicotine attenuates beta-amyloid peptide 1-42-induced activation of GSK-3beta Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-12 cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein tau
-
Rattus norvegicus ADP + protein tau phosphate
-
?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3beta
-
Rattus norvegicus
GSK-3beta
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus