Literature summary for 2.7.11.26 extracted from

Blard, O.; Frebourg, T.; Campion, D.; Lecourtois, M.
Inhibition of proteasome and Shaggy/Glycogen synthase kinase-3beta kinase prevents clearance of phosphorylated tau in Drosophila (2006), J. Neurosci. Res., 84, 1107-1115.

Search for more literature for 2.7.11.26

Application

Application	Comment	Organism
additional information	model of tauopathy in which, depending on toxic challenges (e.g., oxidative stress, exposure to amyloid peptide, etc.), abnormal phosphorylation of tau by kinases distinct from GSK-3beta leads to progressive accumulation of hyperphosphorylated tau oligomers that are resistant to degradation. Sgg activity is required to prevent the accumulation of high-molecular-weight forms of human tau	Drosophila sp. (in: flies)

Cloned(Commentary)

Cloned (Comment)	Organism
coexpression of human tau with a constitutively active form or a dominant-negative form of Sgg	Drosophila sp. (in: flies)

Protein Variants

Protein Variants	Comment	Organism
A81T	kinase-null, dominant negative form of Shaggy, leads to the accumulation of hypophosphorylated high-molecular-weight human tau proteins in old transgenic flies. In young transgenic flies expression results in disappearance of monomeric hyperphosphorylated forms of human tau, concomitantly with the accumulation of monomeric hypophosphorylated forms of human tau	Drosophila sp. (in: flies)
S9A	constitutively active form of Shaggy, drastic upward mobility shift of all monomeric human tau proteins	Drosophila sp. (in: flies)

Organism

Organism	UniProt	Comment	Textmining
Drosophila sp. (in: flies)	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + protein tau	GSK-3beta-mediated hyperphosphorylated forms of tau are degradable by the proteasomal machinery	Drosophila sp. (in: flies)	ADP + protein tau phosphate	-	?

Synonyms

Synonyms	Comment	Organism
glycogen synthase kinase-3beta	-	Drosophila sp. (in: flies)
GSK-3beta	-	Drosophila sp. (in: flies)
Sgg	-	Drosophila sp. (in: flies)
shaggy/zeste white-3	-	Drosophila sp. (in: flies)

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Release 2023.1 (January 2023)