Application | Comment | Organism |
---|---|---|
additional information | phosphorylation of T231 by GSK3beta may play an important role in taus hyperphosphorylation and functional regulation | Mus musculus |
Cloned (Comment) | Organism |
---|---|
His-tagged GSK3beta expressed in Escherichia coli BL21, into pEGFP vector and N18 cells transiently transfected | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | N-terminus negatively regulates tau phosphorlyation by blocking GSK3beta access, local conformational change induced by T231 phosphorylation is required for the phosphorylation of the C-terminus and hyperphosphorylation of tau | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | N18 cell, hyperphosphorylation reduces taus ability to promote tubulin assembly and to form bundles | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + protein tau | T231 is the primary phosphorylation site for GSK3beta, the tau227-237 (AVVRTPPKSPS) derived from tau containing T231P232 motif is the GSK3beta binding site with high affinity (Kd = 0.00082 mmol/L), tau mutant T231A completely abolishes tau phosphorylation by GSK3beta | Mus musculus | ADP + protein tau phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycogen synthase kinase 3beta | - |
Mus musculus |
GSK3beta | - |
Mus musculus |
tau protein kinase I | - |
Mus musculus |