Any feedback?
Literature summary for 2.7.11.26 extracted from
- The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation (2006), J. Biol. Chem., 281, 25457-25465.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | age-dependent increase in tau hyperphosphorylated at the AT-8 site and PHF-1 site, Cdk5 activity does not account for the age-dependent hyperphosphorylation of tau at the disease-related sites, it is mediated by GSK3 activity | Mus musculus |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | disruption of regulation of GSK3 activity underlies tau hyperphosphorylation in neurodegenerative tauopathies. GSK3 may be a prime target for therapeutic intervention in tauopathies including Alzheimer disease | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| p25-induced Cdk5 over-activation of Cdk5 in young and old transgenic mice | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| LiCl | pharmacological inhibition of GSK3 in old transgenic mice by chronic treatment with lithium, leads to a reduction of the age-dependent increase in tau hyperphosphorylation | Mus musculus |  |
| additional information | Cdk5 over-activation leads to inhibition of GSK3 in young transgenic mice, in old transgenic animals the inhibition of GSK3 is lost | Mus musculus | |
| roscovitine | Cdk5 inhibitor | Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
C57BL/6 genetic background | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| hippocampus | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + histone H1 | Cdk5 substrate | Mus musculus | ADP + histone H1 phosphate | - |
? | |
| ATP + phospho-glycogen synthase peptide-2 | GSK3 substrate | Mus musculus | ADP + phosphorylated phospho-glycogen synthase peptide-2 | - |
? | |
| ATP + protein tau | role of GSK3 as a key mediator of tau hyperphosphorylation, whereas Cdk5 acts as a modulator of tau hyperphosphorylation via the inhibitory regulation of GSK3 | Mus musculus | ADP + protein tau phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cdk5 | - |
Mus musculus |
| cyclin-dependent kinase 5 | - |
Mus musculus |
| glycogen synthase kinase 3 | - |
Mus musculus |
| GSK3 | - |
Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
