Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.26 extracted from

  • Chun, J.; Kwon, T.; Lee, E.J.; Kim, C.H.; Han, Y.S.; Hong, S.K.; Hyun, S.; Kang, S.S.
    14-3-3 Protein mediates phosphorylation of microtubule-associated protein tau by serum- and glucocorticoid-induced protein kinase 1 (2004), Mol. Cells, 18, 360-368.
    View publication on PubMed
Search for more literature for 2.7.11.26

Activating Compound

Activating Compound Comment Organism Structure
protein 14-3-3 protein 14-3-3 facilitates tau phosphorylation by SGK1 and regulates its subcellular localization Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of GST-fusion SGK1 in COS-1 cells in the cytoplasm, coexpression with protein 14-3-3 or addition of serum leads to relocation of the enzyme in the nucleus Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens
Mn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [tau-protein] Homo sapiens protein 14-3-3 mediates phosphorylation of microtubule-associated protein tau by serum- and glucocorticoid-induced protein kinase 1 SGK1, which forms an activated ternary complex with protein 14-3-3theta ADP + O-phospho-[tau-protein]
-
 ?
additional information Homo sapiens protein 14-3-3 facilitates tau phosphorylation by SGK1 and regulates its subcellular localization in the nucleus or cytoplasm, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + FITC-GSRSRTPSLP synthetic fluorescence-labeled peptide substrate derived from residues 207-216 of tau protein, phosphorylation of S214 by SGK1 Homo sapiens ADP + FITC-GSRSRTP-phosphoserine-LP
-
 ?
ATP + [tau-protein] protein 14-3-3 mediates phosphorylation of microtubule-associated protein tau by serum- and glucocorticoid-induced protein kinase 1 SGK1, which forms an activated ternary complex with protein 14-3-3theta Homo sapiens ADP + O-phospho-[tau-protein]
-
 ?
ATP + [tau-protein] phosphorylation of S214 by SGK1, recombinant tau S214A is no substrate Homo sapiens ADP + O-phospho-[tau-protein]
-
 ?
additional information protein 14-3-3 facilitates tau phosphorylation by SGK1 and regulates its subcellular localization in the nucleus or cytoplasm, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
protein kinase 1
-
 Homo sapiens
serum- and glucocorticoid-induced protein kinase 1
-
 Homo sapiens
SGK1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
95
-
 10 min, inactivation Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens