Activating Compound | Comment | Organism | Structure |
---|---|---|---|
p25 | activator required for CDK5 activity, activation of CDK5 by p25 which is activated by cleavage of p35 to p25 | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
co-expression of dominant negative EGFP-tagged CDK5 and p25 in PC12 cells | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
roscovitine | inhibition of CDK5 | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Rattus norvegicus | 5737 | - |
microtubule | - |
Rattus norvegicus | 5874 | - |
additional information | CDK5-dependent clustering of endoplasmic reticulum ER and mitochondria and translocation to the centrosome during ceramide-mediated neuronal death | Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [tau-protein] | Rattus norvegicus | tau is microtubule-associated, phopshorylation at T231 by CDK5 causes its release into the cytoplasm | ADP + O-phospho-[tau-protein] | - |
? | |
additional information | Rattus norvegicus | CDK5-dependent clustering of endoplasmic reticulum ER and mitochondria during ceramide-mediated neuronal death: neurotoxic calcium transfer from ER to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau, inhibition of the process leads to cell death | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
pregnant Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | primary midbrain mesencephalonic cells | Rattus norvegicus | - |
neuron | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [tau-protein] | tau is microtubule-associated, phopshorylation at T231 by CDK5 causes its release into the cytoplasm | Rattus norvegicus | ADP + O-phospho-[tau-protein] | - |
? | |
ATP + [tau-protein] | phosphorylation at T231, no activity with tau mutant T231A | Rattus norvegicus | ADP + O-phospho-[tau-protein] | - |
? | |
additional information | CDK5-dependent clustering of endoplasmic reticulum ER and mitochondria during ceramide-mediated neuronal death: neurotoxic calcium transfer from ER to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau, inhibition of the process leads to cell death | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cdk5 | - |
Rattus norvegicus |
cyclin-dependent kinase 5 | - |
Rattus norvegicus |
More | see also EC 2.7.11.22 | Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |