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Literature summary for 2.7.11.26 extracted from

  • Darios, F.; Muriel, M.P.; Khondiker, M.E.; Brice, A.; Ruberg, M.
    Neurotoxic calcium transfer from endoplasmic reticulum to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau (2005), J. Neurosci., 25, 4159-4168.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
p25 activator required for CDK5 activity, activation of CDK5 by p25 which is activated by cleavage of p35 to p25 Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
co-expression of dominant negative EGFP-tagged CDK5 and p25 in PC12 cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
roscovitine inhibition of CDK5 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Rattus norvegicus 5737
-
microtubule
-
Rattus norvegicus 5874
-
additional information CDK5-dependent clustering of endoplasmic reticulum ER and mitochondria and translocation to the centrosome during ceramide-mediated neuronal death Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [tau-protein] Rattus norvegicus tau is microtubule-associated, phopshorylation at T231 by CDK5 causes its release into the cytoplasm ADP + O-phospho-[tau-protein]
-
?
additional information Rattus norvegicus CDK5-dependent clustering of endoplasmic reticulum ER and mitochondria during ceramide-mediated neuronal death: neurotoxic calcium transfer from ER to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau, inhibition of the process leads to cell death ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
pregnant Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture primary midbrain mesencephalonic cells Rattus norvegicus
-
neuron
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [tau-protein] tau is microtubule-associated, phopshorylation at T231 by CDK5 causes its release into the cytoplasm Rattus norvegicus ADP + O-phospho-[tau-protein]
-
?
ATP + [tau-protein] phosphorylation at T231, no activity with tau mutant T231A Rattus norvegicus ADP + O-phospho-[tau-protein]
-
?
additional information CDK5-dependent clustering of endoplasmic reticulum ER and mitochondria during ceramide-mediated neuronal death: neurotoxic calcium transfer from ER to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau, inhibition of the process leads to cell death Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
Cdk5
-
Rattus norvegicus
cyclin-dependent kinase 5
-
Rattus norvegicus
More see also EC 2.7.11.22 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus